111043-99-3Relevant academic research and scientific papers
A convenient route to chiral γ-lactones via asymmetric hydrogenation of γ-ketoesters using the RuCl3-BINAP-HCl catalytic system
Starodubtseva, Eugenia V.,Turova, Olga V.,Vinogradov, Maxim G.,Gorshkova, Lilia S.,Ferapontov, Vladimir A.,Struchkova, Marina I.
, p. 11713 - 11717 (2008)
A convenient one-step synthesis of chiral γ-lactones has been performed. The method is based on enantioselective hydrogenation of γ-ketoesters using the RuCl3-BINAP-HCl catalytic system. Chiral γ-lactones (91-99% ee) have been isolated in 57-88% yield.
Preparation of synthetically useful chiral building blocks - 5-alkylated γ-lactones via catalytic asymmetric hydrogenation of 4-oxo esters
Juszkiewicz,Asztemborska,Jurczak
, p. 1707 - 1711 (2007/10/03)
Asymmetric hydrogenation of 4-oxo esters, catalyzed by cationic BINAP-Ru(II) complexes, afforded in a good overall yield and with excellent enantioselectivity (> 98% ee), the respective 5-alkylated γ-lactones, useful intermediates for the preparation of pheromones.
