111049-68-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-AMINO-5-BROMO-2-METHOXYBENZENECARBOXYLATE is used as a building block for the synthesis of novel heterocyclic compounds, which have potential applications in the development of new pharmaceuticals. Its unique chemical structure allows for the creation of diverse compounds with various therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, METHYL 4-AMINO-5-BROMO-2-METHOXYBENZENECARBOXYLATE serves as a key intermediate in the synthesis of various agrochemicals, such as pesticides and herbicides. Its ability to form heterocyclic compounds makes it a valuable component in the development of effective and environmentally friendly agrochemicals.
Used in Dye and Pigment Industry:
METHYL 4-AMINO-5-BROMO-2-METHOXYBENZENECARBOXYLATE is used as an intermediate in the preparation of dyes and pigments, contributing to the development of new colorants with improved properties. Its versatility in chemical reactions enables the creation of a wide range of colors and shades for various applications, including textiles, plastics, and printing inks.
Used in Chemical Product Industry:
As an intermediate in the synthesis of various chemical products, METHYL 4-AMINO-5-BROMO-2-METHOXYBENZENECARBOXYLATE plays a crucial role in the development of new materials and compounds with specific properties. Its involvement in the production of these products highlights its importance in the chemical industry and its potential for further applications in various fields.

Upstream product

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 

Downstream Products

• 111049-67-3 methyl 2-methoxy 4-isothiocyanato 5-bromo benzoate 
• 1485749-42-5 N-[4-[8-amino-6-[1-(difluoromethyl)cyclopropyl]-5-methoxy-3-quinolyl]phenyl]methanesulfonamide 
• 1485749-39-0 tert-butyl N-[6-[1-(difluoromethyl)cyclopropyl]-3-[4-(methanesulfonamido)phenyl]-5-methoxy-8-quinolyl]carbamate 
• 1485749-36-7 N-[4-[8-bromo-6-[1-(difluoromethyl)cyclopropyl]-5-methoxy-3-quinolyl]phenyl]methanesulfonamide 
• 1257833-31-0 N-[4-[6-[1-(Difluoromethyl)cyclopropyl]-8-(2,4-dioxopyrimidin-1-yl)-5-methoxy-3-quinolyl]phenyl]methanesulfonamide 
• 35290-97-2 4-amino 5-bromo 2-methoxy benzoic acid 

Relevant academic research and scientific papers

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

Visible-light-promoted oxidative halogenation of (hetero)arenes

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.