1110652-59-9Relevant academic research and scientific papers
Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity
Long, Yun Oliver,Higuchi, Robert I.,Caferro, Thomas R.,Lau, Thomas L.S.,Wu, Min,Cummings, Marquis L.,Martinborough, Esther A.,Marschke, Keith B.,Chang, William Y.,Lopez, Francisco J.,Karanewsky, Donald S.,Zhi, Lin
, p. 2967 - 2971 (2008/12/22)
Modification on a lead series of [1,4]oxazino[3,2-g]quinolin-7-ones at the 2-position led to selective androgen receptor modulators with improved in vivo activity. The most potent analog (-)-33a exhibited full maintenance of levator ani muscle at 3 mg/kg and reduced activity on ventral prostate weight in a 2-week orally-dosed and orchidectomized rat maintenance assay.
