1110772-05-8

Basic information

• Product Name: (1R,3S)-3-Aminocyclopentanol
• Synonyms: (1R,3S)-3-Aminocyclopentanol;Cyclopentanol, 3-aMino-, (1R,3S)-;(1R,3S)-3-aMinocyclopentan-1-ol hydrochloride;(1R,3S)-3-Amino-cyclohexanol hydrochloride;(1R,3S)-3-Aminocyclopentanol(WX600234)
• CAS NO: 1110772-05-8
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101
• Product Categories: organic building block
• Mol File: 1110772-05-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 179℃
• Flash Point: 62℃
• Appearance: /
• Density: 1.084
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.06±0.40(Predicted)
• CAS DataBase Reference: (1R,3S)-3-Aminocyclopentanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S)-3-Aminocyclopentanol(1110772-05-8)
• EPA Substance Registry System: (1R,3S)-3-Aminocyclopentanol(1110772-05-8)

Safety Data

• Hazardous Substances Data: 1110772-05-8(Hazardous Substances Data)

Usage

Uses

(1R,3S)-3-Aminocyclopentanol is a Bictegravir (1611493-60-7) intermediate and an antiviral agent.

Upstream product

• 121129-35-9 2-Mandeloyl-3,6-dihydro-3,6-methano-2H-1,2-oxazine 
• 121129-38-2 2-(tert-Butylglycoloyl)-3,6-dihydro-3,6-methano-2H-1,2-oxazine 
• 167298-58-0 (±)-cis-3-aminocyclopentanol 
• 126924-22-9 (1S,4R,αR-)-3-(α-hydroxyphenylacetyl)-2-oxa-3-aza-bicyclo[2,2,1]hept-5-ene 
• 542-92-7 cyclopenta-1,3-diene 
• 160167-65-7 cis-3(S)-(N-D-Alanylamino)cyclopentan-1(R)-ol 

Downstream Products

• 167465-99-8 (1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester 
• 1279032-31-3 (1R,3S)-3-amino-1-cyclopentanol hydrochloride 
• 1616342-45-0 (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid 
• 1443749-28-7 C₄₂H₄₄Cl₂FN₃O₄ 
• 1443749-22-1 (2'S,3R,4'S,5'R)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((1S,3R)-3-hydroxycyclopentyl)-2'-neopentyl-2-oxospiro-[indoline-3,3'-pyrrolidine]-5'-carboxamide 
• 1303605-80-2 MI-519-51 

Relevant articles and documents

Preparation method of (1R,3S)-3-amino-1-cyclopentanol and salt thereof

The invention discloses a preparation method of (1R,3S)-3-amino-1-cyclopentanol and a salt thereof, and relates to the field of organic synthesis. In the method, a chiral source in an N-Acyl hydroxylamine compound is used as chiral induction, and an asymm

Preparation of optically-pure cyclic amino alcohol and salt thereof

The invention relates to the field of chemical pharmacy, in particular to a method for preparing an optically-pure cyclic amino alcohol and a salt thereof. The method comprises: 1) catalytic hydrogenation: a compound (12) is subjected to catalytic hydroge

A (1 R, 3 S) -3 - amino-cyclopentanol hydrochloride preparation method (by machine translation)

The invention discloses a (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride of the preparation method, the method using chiral carboxylic acid with hydroxylamine to form the amide as chiral source, in copper catalyzed oxidation in the reaction system to rapidly obtain a chiral Diels - alder reaction product, after passes through the reduction reaction and alkaline deprotection reaction, and acidified after reaction to obtain the target product. Chiral inducing reagent chiral carboxylic acid by simple acidification, extraction processing can be reclaimed and reused. This kind of (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride preparation method has high operation safety and high selectivity, raw materials are easy, and the cost is low, the reaction time is short and simple process flow and the like. (by machine translation)