1110775-91-1

Upstream product

• 1110775-81-9 tert-butyl 5-bromo-3-[2-(diethylamino)ethoxy]-2-methyl-1H-indole-1-carboxylate 
• 100-46-9 benzylamine 

Downstream Products

• 1110776-21-0 tert-butyl 5-{[(1-benzothiophen-3-yl)sulfonyl](benzyl)amino}-3-[2-(diethylamino)ethoxy]-2-methyl-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Substituted indole sulfonamide compounds their preparation and use as medicaments

The present invention relates to indole sulfonamide compounds of general formula (I), a process for their preparation, a medicament comprising these compounds and the use of the indole sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.

Palladium-catalyzed amination and sulfonylation of 5-bromo-3-[2- (diethylamino)ethoxy]indoles to potential 5-HT6 receptor ligands

A general and efficient palladium-catalyzed amination of 5-bromo-3-[2-(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)2 and 2-[di(1-adamantyl) phosphanyl]-1-phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivatives, which are of interest as potentially biological active 5-HT6 receptor ligands. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.