111079-19-7

Basic information

• Product Name: 4-Chloro-5-iodo-2-methylthiopyrimidine
• Synonyms: 4-Chloro-5-iodo-2-methylthiopyrimidine;4-chloro-5-iodo-2-methylsulfanylpyrimidine
• CAS NO: 111079-19-7
• Molecular Formula: C₅H₄ClIN₂S
• Molecular Weight: 286.52113
• Mol File: 111079-19-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63.5-64.5 °C
• Boiling Point: 331.1±22.0 °C(Predicted)
• Appearance: /
• Density: 2.09±0.1 g/cm3(Predicted)
• PKA: -1.91±0.29(Predicted)
• CAS DataBase Reference: 4-Chloro-5-iodo-2-methylthiopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-iodo-2-methylthiopyrimidine(111079-19-7)
• EPA Substance Registry System: 4-Chloro-5-iodo-2-methylthiopyrimidine(111079-19-7)

Safety Data

• Hazardous Substances Data: 111079-19-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-iodo-2-methylthiopyrimidine is a chemical compound with the molecular formula C6H4ClIN2S. It is a heterocyclic organic compound that contains both chlorine and iodine atoms, as well as a methylthio group. 4-Chloro-5-iodo-2-methylthiopyrimidine is used in organic synthesis and medicinal chemistry, and it has potential applications in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. It is a yellow solid with a molecular weight of 282.52 g/mol and a melting point of 139-141°C. The chemical structure of 4-Chloro-5-iodo-2-methylthiopyrimidine makes it a valuable precursor for the preparation of various pharmaceuticals and agrochemicals.

Upstream product

• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 
• 5751-20-2 2-Methylthiouracil 
• 76510-61-7 5-iodo-4-hydroxy-6-methyl-2-methylthiopyrimidine 

Downstream Products

• 864543-58-8 (4-chlorophenyl)-(4-chloro-2-methylsulfanylpyrimidin-5-yl)methanone 

Relevant articles and documents

A New Synthesis of 2-Aminoindoles and 6-Aminopyrrolo[3,2- d ]pyrimidines from π-Deficient 1,2-Dihaloarenes and Geminal Enediamines

An efficient approach for the synthesis of fused 2-aminopyrroles via geminal enediamines and π-deficient 1,2-dihaloarenes is presented. The two-step methodology includes aromatic nucleophilic substitution of the activated halogen of dihaloarene with enediamine C-nucleophilic center followed by Cu-catalyzed intramolecular N-arylation. This approach allows access to a variety of 2-amino-6-nitroindoles and 6-aminopyrrolo[3,2-d]pyrimidines (including N-mono- and N,N-disubstituted) in moderate and good yields under mild conditions.

A class of pyrazolopyrimidine diazepine derivatives with antitumor effect

The present invention relates to the field of medicine, wherein a pyrazolopyrimidine diazepine derivative represented by a formula I can significantly inhibit three targets such as Aurora A, Aurora Band vascular endothelial growth factor receptor 2 (VEGFR2/KDR), or two or one of the three targets, and the pharmacological experiment results show that the pyrazolopyrimidine diazepine derivative hassignificant antitumor activity, can be used to be developed into antitumor drugs for treatment or control of malignant tumors, especially drugs for treatment or control of gastric cancer, liver cancer, lung cancer, breast cancer, colon cancer and the like. The formula I is defined in the specification.

CONDENSED HETEROAROMATIC RING SYSTEMS. VII. SYNTHESIS OF THIENOPYRIDINES, THIENOPYRIMIDINES, AND FUROPYRIDINES FROM o-SUBSTITUTED N-HETEROARYLACETYLENES

The cross-coupling reaction of 2-chloro-3-iodo- and 4-chloro-3iodopyridines with phenylacetylene in the presence of dichlorobis(triphenylphosphine)palladium occured at the 3-position.The 3-ethynylpyridines containing an adjacent chloro group were converti