111079-44-8

Basic information

• Product Name: 2-(Trimethylsilyl)furo[3,2-b]pyridine
• Synonyms: 2-(Trimethylsilyl)furo[3,2-b]pyridine
• CAS NO: 111079-44-8
• Molecular Formula: C₁₀H₁₃NOSi
• Molecular Weight: 191
• Mol File: 111079-44-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 248℃
• Flash Point: 104℃
• Appearance: /
• Density: 1.03
• CAS DataBase Reference: 2-(Trimethylsilyl)furo[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trimethylsilyl)furo[3,2-b]pyridine(111079-44-8)
• EPA Substance Registry System: 2-(Trimethylsilyl)furo[3,2-b]pyridine(111079-44-8)

Safety Data

• Hazardous Substances Data: 111079-44-8(Hazardous Substances Data)

Usage

General Description

2-(Trimethylsilyl)furo[3,2-b]pyridine is an organosilicon compound that has a unique structure combining a furan and pyridine ring. It is commonly used as a reagent in organic synthesis reactions, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. The trimethylsilyl group attached to the furan ring makes the compound highly reactive, allowing it to participate in a variety of chemical reactions. Its versatile reactivity and ability to selectively participate in specific bond-forming reactions make it a valuable tool in the field of organic chemistry. Additionally, 2-(trimethylsilyl)furo[3,2-b]pyridine can also be used as a protecting group for alcohols, amines, and carboxylic acids in organic synthesis.

Upstream product

• 272-62-8 furo[3,2-b]pyridine 
• 75-77-4 chloro-trimethyl-silane 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 1066-54-2 trimethylsilylacetylene 
• 40263-57-8 2-iodo-3-hydroxypyridine 

Downstream Products

• 1360904-14-8 7-chloro-2-(3,4,5-trimethoxy-phenyl)furo[3,2-b]pyridine 
• 1360904-18-2 7-phenyl-2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridine 
• 1360905-84-5 2,7-bis-(3,5-difluoro-phenyl)-furo[3,2-b]pyridine 
• 1360911-14-3 7-chloro-2-(4-fluoro-phenyl)-furo[3,2-b]pyridine 
• 1360905-97-0 2,2-difluoro-6-[2-(3,4,5-trimethoxy-phenyl)-furo[3,2-b]pyridin-7-ylamino]-4H-benzo[1,4]oxazin-3-one 
• 1360907-28-3 3-[7-(4-phenoxyphenoxy)furo[3,2-b]pyridin-2-yl]aniline 
• 1360911-36-9 3-(7-chlorofuro[3,2-b]pyridin-2-yl)aniline 
• 1360907-30-7 N-{3-[7-(4-phenoxyphenoxy)furo[3,2-b]pyridin-2-yl]phenyl}propanamide 
• 1360907-34-1 N-{3-[7-(4-phenoxyphenoxy)furo[3,2-b]pyridin-2-yl]phenyl}acrylamide 
• 1360907-39-6 N-{3-[7-(4-phenoxyphenoxy)furo[3,2-b]pyridin-2-yl]phenyl}but-2-ynamide 
• 1360910-74-2 2-chloro-N-{3-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acetamide 
• 1360910-75-3 N-{2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenyl}-acrylamide 
• 1360911-37-0 2-(7-chloro-furo[3,2-b]pyridin-2-yl)-phenylamine 
• 1360911-38-1 2-[7-(4-phenoxy-phenoxy)-furo[3,2-b]pyridin-2-yl]-phenylamine 

Relevant articles and documents

NOVEL JAK1 SELECTIVE INHIBITORS AND USES THEREOF

The new 1H-furo[3,2-b]imidazo[4,5-d]pyridine derivatives are selective Jak1 kinase inhibitors useful in treating disorders related to Jak1 activities such as autoimmune diseases or disorders, inflammatory diseases or disorders, and cancer or neoplastic di

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

FURO [3, 2 - B] - AND THIENO [3, 2 - B] PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS

Compounds of the formula (I) in which R1, R2 and X have the meanings indicated in Claim 1, are inhibitors of TBK1 and ΙΚΚε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.