111097-54-2Relevant articles and documents
Novel triazole derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating Aurora Kinase relating diseases containing the same as an active ingredient
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Paragraph 0177, (2017/08/02)
The present invention relates to a novel triazole derivative, a production method thereof, and an aurora kinase-associated pharmaceutical composition containing the same as an active ingredient. According to the present invention, the novel triazole derivative, an optical isomer thereof, or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activities as aurora kinase at nanomolar scale, thereby showing effectiveness in the treatment of various types of cancer or tumor as the pharmaceutical composition containing the same.COPYRIGHT KIPO 2017
RING-TRANSFORMATIONS OF PYRIMIDINES BY INTRAMOLECULAR DIELS-ALDER REACTIONS. SYNTHESIS OF ANNELATED PYRIDINES
Frissen, A. E.,Marcelis, A. T. M.,Plas, H. C. van der
, p. 803 - 812 (2007/10/02)
Pyrimidines carrying an ω-alkyne side-chain -XCH2CH2CCH (X=O,N,S,SO,SO2) at the 2 or 5 position undergo intramolecular inverse electron demand Diels-Alder reactions across the C-2 and C-5 positions; elimination of hydrogen (or alkyl) cyanide from the intermediate adducts leads to condensed pyridines.The influence of the hetero atom (X) in the dienophilic side-chain and that of substituents in the pyrimidine ring on the reactivity is discussed.