111097-63-3Relevant academic research and scientific papers
DIASTEREOSELECTIVE ALKYLATION OF THE DIANION OF 5-ETHOXY-4(S)-HYDROXY-1-ISOPROPYL-2-PYRROLIDINONE; SHYNTHESIS OF ENANTIOMERICALLY PURE AZABICYCLES
Klaver, Wim J.,Hiemstra, Henk,Speckamp, Nico
, p. 1581 - 1584 (2007/10/02)
The alkylation of the dianion of the title compound (2), readily prepared from (S)-malic acid, with ω-iodo-1-trimethylsilyl-2-alkynes (8a-c) occurs with high trans-selectivity with respect to the hydroxyl function.The products (11a-c) cyclize in formic acid to enantiomerically pure azabicyclic allenes (12a-c), one of which (12b) might be a suitable precursor to peduncularine (15).
