1111-92-8 Usage
Chemical Description
Dimethylphosphinic chloride and Diphenylphosphinous chloride are phosphinic chlorides, while alkylphosphonates and phosphonic dichlorides are esters and acids, respectively.
Chemical Properties
yellow to pink to tan crystals or crystalline
Uses
Different sources of media describe the Uses of 1111-92-8 differently. You can refer to the following data:
1. Dimethylphosphinic chloride is used in the protection of amino acids in peptide synthesis. It initiates the luminescence of ABI-NH2. It is utilized in the reactivity of organophosphate-based nerve gases such as sarin gas.
2. Dimethylphosphinic chloride was used in preparation of dimethyl-ethynylphosphine oxide.
General Description
Kinetics of pyridinolyses of dimethylphosphinic chloride in acetonitrile was studied. Kinetics and mechanism of the reaction of dimethyl phosphinic chloride with anilines in acetonitrile was studied.
Check Digit Verification of cas no
The CAS Registry Mumber 1111-92-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,1 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1111-92:
(6*1)+(5*1)+(4*1)+(3*1)+(2*9)+(1*2)=38
38 % 10 = 8
So 1111-92-8 is a valid CAS Registry Number.
InChI:InChI=1/C2H6ClOP/c1-5(2,3)4/h1-2H3
1111-92-8Relevant articles and documents
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Burg,A.B.,Slota,P.J.
, p. 2145 - 2148 (1960)
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METHYLPHOSPHINYL (Dmp): A NEW PROTECTING GROUP OF TYROSINE SUITABLE FOR PEPTIDE SYNTHESIS BY USE OF BOC-AMINO ACIDS
Ueki, Masaaki,Sano, Yoshiyuki,Sori, Ichiro,Shinozaki, Kozo,Oyamada,Hidekazu,Ikeda, Shigeru
, p. 4181 - 4184 (2007/10/02)
Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied.The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF.
Evaluation of Phosphinic Acid Derivatives as Reagents For Amine Protection in Peptide Synthesis
Ramage, Robert,Atrash, Butrus,Hopton, David,Parrot, Maxwell J.
, p. 1217 - 1226 (2007/10/02)
The results of a kinetic study of the acid-catalysed methanolysis of a series of N-(2-phenyl-ethyl)phosphinamides incorporating selected substituents on phosphorus have been evaluated in order to define the optimum reagent and conditions for amine protection of α-amino acids during peptide synthesis.
