111102-67-1Relevant academic research and scientific papers
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors
Dales, Natalie A.,Gould, Alexandra E.,Brown, James A.,Calderwood, Emily F.,Guan, Bing,Minor, Charles A.,Gavin, James M.,Hales, Paul,Kaushik, Virendar K.,Stewart, Michael,Tummino, Peter J.,Vickers, Chad S.,Ocain, Timothy D.,Patane, Michael A.
, p. 11852 - 11853 (2007/10/03)
Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and se
Synthesis and Structure-Activity Relationships of a Novel Series of Non-Peptide Angiotensin II Receptor Binding Inhibitors Specific for the AT2 Subtype
Blankley, C. John,Hodges, John C.,Klutchko, Sylvester R.,Himmelsbach, Richard J.,Chucholowski, Alexander,et al.
, p. 3248 - 3260 (2007/10/02)
Structure-activity relationships are reported for a novel class of 4,5,6,7-tetrahydro-1H-imidazopyridine-6-carboxylic acid derivatives that displace 125I-labeled angiotensin II from a specific subset of angiotensin II (Ang II) binding sites in rat
Regiospecific Synthesis of 3-Substituted L-Histidines
Hodges, John C.
, p. 20 - 24 (2007/10/02)
3-Substituted L-histidine derivatives were prepared by a regiospecific alkylation of N,1-bis-Boc-L-histidine methyl ester with in situ-generated alkyl triflates, benzyl triflates, and benzyl mesylates.Subsequent acid hydrolysis of N-Boc and methyl ester p
