1111072-22-0Relevant academic research and scientific papers
Iodotrifluoromethylation of alkenes and alkynes with sodium trifluoromethanesulfinate and iodine pentoxide
Hang, Zhaojia,Li, Zejiang,Liu, Zhong-Quan
supporting information, p. 3648 - 3651 (2014/08/05)
A scalable, selective, and operationally easy iodotrifluoromethylation of a wide range of alkenes and alkynes by using two simple and safe solids, sodium trifluoromethanesulfinate and iodine pentoxide, in aqueous medium has been developed. Mechanistic studies confirm that free-radical processes are involved in this system since the key radical intermediates such as CF3 and β-CF3 alkyl radicals have been clearly detected by spin trapping and electron spin resonance.
Regio- and stereo-specific preparation of (E)-1-aryl-3,3,3-trifluoro-1-iodo-propenes and their palladium-catalyzed reaction with terminal alkynes
Zhang, Xing-Guo,Chen, Mu-Wang,Zhong, Ping,Hu, Mao-Lin
, p. 335 - 342 (2008/12/22)
A new type of iodo-containing trifluoromethylated building blocks were synthesized. The reaction of 1-aryl-3,3,3-trifluoropropynes 1 with lithium iodide in acetic acid at 75 °C gave (E)-1-aryl-3,3,3-trifluoro-1-iodo-propenes 2 in high yield, which undergo the palladium-catalyzed Sonogashira reaction with terminal alkynes afforded trifluoromethyl-containing 1,3-enynes in high yield.
