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1111092-50-2

[(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone, also known as PNU 282987, is a synthetic chemical compound that serves as a potent and selective agonist at the α7 nicotinic acetylcholine receptor. This receptor, found in the brain, plays a crucial role in cognitive function, making PNU 282987 a promising candidate for the treatment of cognitive disorders such as Alzheimer's disease and schizophrenia. Its unique structure and mechanism of action have made it an essential tool in neuropharmacology research and drug development for cognitive disorders.

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  • 1111092-50-2 Structure

  • Basic information

    1. Product Name: [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone
    2. Synonyms: [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone
    3. CAS NO:1111092-50-2
    4. Molecular Formula:
    5. Molecular Weight: 361.444
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1111092-50-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone(1111092-50-2)
    11. EPA Substance Registry System: [(S)-2-(hydroxydiphenylmethyl)-pyrrolidin-1-yl]-(1-methyl-1H-imidazol-2-yl)methanone(1111092-50-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1111092-50-2(Hazardous Substances Data)

1111092-50-2 Usage

Uses

Used in Pharmaceutical Industry:
PNU 282987 is used as a therapeutic agent for the treatment of cognitive disorders such as Alzheimer's disease and schizophrenia. Its agonist activity at the α7 nicotinic acetylcholine receptor has shown promising results in improving memory and cognitive function in preclinical and clinical trials.
Used in Neuropharmacology Research:
PNU 282987 is used as a research tool in neuropharmacology to study the role of the α7 nicotinic acetylcholine receptor in cognitive function and to develop new drugs for the treatment of cognitive disorders.
Used in Drug Development:
PNU 282987 is utilized in the development of new drugs targeting the α7 nicotinic acetylcholine receptor, with the aim of creating more effective treatments for cognitive disorders and potentially other conditions related to cognitive impairment.

Check Digit Verification of cas no

The CAS Registry Mumber 1111092-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,1,0,9 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1111092-50:
(9*1)+(8*1)+(7*1)+(6*1)+(5*0)+(4*9)+(3*2)+(2*5)+(1*0)=82
82 % 10 = 2
So 1111092-50-2 is a valid CAS Registry Number.

1111092-50-2Relevant articles and documents

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

Gautier, Franois-Moana,Jones, Simon,Martin, Stephen J.

, p. 229 - 231 (2009)

Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.

CATALYST COMPOUNDS

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Page/Page column 20, (2013/06/27)

The present invention relates to compounds, particularly but not exclusively, compounds for use as catalysts, methods for producing said compounds and the use of said compounds as catalysts in catalytic processes including, but not limited to, the asymmetric reduction of imine and enamine compounds and/or the reductive amination of ketone compounds. The compounds have the formula 1 wherein: R1, R2, R3, R4 and R5 are each separately selected from the group consisting of hydrogen, alkyl and aryl; X is oxygen or sulfur; W is selected from the group consisting of – OR18,–SR18, –NR19R20, –PR19R20 where R18 is alkyl or aryl, and R19 and R20 are each separately selected from the group consisting of hydrogen, alkyl and aryl; and Z has the formula 2 wherein: R6 and R7 are each separately selected from the group consisting of hydrogen, alkoxy, nitro, halogen, alkyl and aryl, or R6 and R7 are linked to form a cyclic group; and Y is oxygen, sulfur or NR10 in which R10 is selected from the group consisting of hydrogen, alkyl and aryl.

CATALYST COMPOUNDS

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Page/Page column 26, (2009/04/25)

The present invention relates to compounds for use as catalysts, methods for producing said compounds and the use of said compounds as catalysts in catalytic processes including, but not limited to, the asymmetric reduction of imine and enamine compounds

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