The structure (2) of roridin L-2 is shown to be a C29-trichothecene that lacks the macrocyclic lactone system usually present in the roridins.detailed
Roridin A (1) and verrucarin A (2), inhibitors of pollen development in Arabidopsis thaliana, have been isolated from the fungus Cylindrocarpon sp. They inhibited the pollen development at concentrations of 2 and 20 μM, respectively. The microscopic examination of pollen development suggested t...detailed
Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12’-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human mo...detailed
The widespread use of synthetic nematicides has caused significant problems to the environment as well as human health. To address this issue, eco-friendly control measures, such as microbial nematicides, are being developed. During the screening of Myrothecium strains with nematicidal activity ...detailed
The (2′Z)-configuration of roridin J (1) was revised to the (2′E) form by conducting NOE experiments. Although the configurations with respect to the stereogenic carbons on the macrocyclic ring of 1 had remained unknown, a combination of NMR analysis and molecular modeling calculations reveale...detailed