111140-92-2 Usage
Uses
Used in Pharmaceutical Industry:
3-(4-Carbamoylphenoxy)propionic Acid is used as an antihypertensive agent for the treatment of high blood pressure. It functions by blocking the action of angiotensin, a natural substance that constricts blood vessels and elevates blood pressure, thereby helping to maintain a healthy cardiovascular system.
3-(4-Carbamoylphenoxy)propionic Acid is also used as a preventive measure for heart attacks, strokes, and kidney problems. Its ability to block angiotensin II receptors helps in reducing the risk of these serious health conditions, especially in patients with hypertension.
Additionally, 3-(4-Carbamoylphenoxy)propionic Acid is utilized in combination therapy with other medications to achieve better control of hypertension. This approach allows for the optimization of treatment efficacy and the management of side effects, ensuring a more effective and safer treatment regimen for patients with high blood pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 111140-92-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,1,4 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 111140-92:
(8*1)+(7*1)+(6*1)+(5*1)+(4*4)+(3*0)+(2*9)+(1*2)=62
62 % 10 = 2
So 111140-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO4/c11-10(14)7-1-3-8(4-2-7)15-6-5-9(12)13/h1-4H,5-6H2,(H2,11,14)(H,12,13)
111140-92-2Relevant academic research and scientific papers
Spiro hydantoin aldose reductase inhibitors
Sarges,Schnur,Belletire,Peterson
, p. 230 - 243 (2007/10/02)
Sorbitol formation from glucose, catalyzed by the enzyme aldose reductase, is believed to play a role in the development of certain chronic complications of diabetes mellitus. Spiro hydantoin derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens. In vivo these compounds are potent inhibitors of sorbitol formation in sciatic nerves of streptozotocinized rats. Optimum in vivo activity is reached in spiro hydantoins derived from 6-halogenated 2,3-dihydro-4H-1-benzopyran-4-ones (4-chromanones). In 2,4-dihydro-6-fluorospirol[4H-1-benzopyran-4,4'-imidazolidine]-2',5'- ione, the activity resides exclusively in the 4S isomer, compound 115 (CP-45,634, USAN: sorbinil). This compound is currently being used to test, in humans, the value of aldose reductase inhibitors in the therapy of diabetic complications.
