1111598-02-7 Usage
General Description
The chemical (2-Amino-1-cyclohexyl-ethyl)-carbamic acid tert-butyl ester, also known as cyclobutane carboxylic acid, is an organic compound with the chemical formula C11H21NO2. It is a white to off-white solid that is slightly soluble in water and has a strong odor. (2-Amino-1-cyclohexyl-ethyl)-carbamic acid tert-butyl ester is commonly used as a reactant in the synthesis of pharmaceuticals and agrochemicals, and as an intermediate in the production of various other chemicals. It is also used as a reagent in organic chemistry reactions. However, it is important to handle this compound with care, as it may be harmful if ingested, inhaled, or in contact with the skin.
Check Digit Verification of cas no
The CAS Registry Mumber 1111598-02-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,1,5,9 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1111598-02:
(9*1)+(8*1)+(7*1)+(6*1)+(5*5)+(4*9)+(3*8)+(2*0)+(1*2)=117
117 % 10 = 7
So 1111598-02-7 is a valid CAS Registry Number.
1111598-02-7Relevant articles and documents
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings
Chen, Kevin X.,Vibulbhan, Bancha,Yang, Weiying,Nair, Latha G.,Tong, Xiao,Cheng, Kuo-Chi,Njoroge, F. George
body text, p. 1105 - 1109 (2009/08/07)
Extensive SAR studies of the P3 capping group led to the discovery of a series of potent inhibitors with sultam and cyclic sulfonyl urea moieties as the P3 capping. The bicyclic thiophene-sultam or phenyl-sultam cappings were selected for further SAR development. Modification at the P3 side chain determined that the tert-butyl group was the best choice at that position. Optimization of P1 residue significantly improved potency and selectivity. The combination of optimal moieties at all positions led to the discovery of compound 33. This compound had the best overall profile in potency and PK profile: excellent Ki* of 5.3 nM and activity in replicon (EC90) of 80 nM, extremely high selectivity of 6100, and a good rat PO AUC of 1.43 μM h.
