1111636-35-1

Basic information

• Product Name: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
• Synonyms: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;PF-04880594;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;PF-04880594/PF04880594
• CAS NO: 1111636-35-1
• Molecular Formula: C₁₉H₁₆F₂N₈
• Molecular Weight: 393.3728064
• Mol File: 1111636-35-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• Storage Temp.: room temp
• PKA: 12.99±0.40(Predicted)
• CAS DataBase Reference: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-(1111636-35-1)
• EPA Substance Registry System: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-(1111636-35-1)

Safety Data

• Hazardous Substances Data: 1111636-35-1(Hazardous Substances Data)

Usage

Uses

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors.

Biochem/physiol Actions

PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.

Upstream product

• 754214-56-7 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1111638-19-7 3-(4-(1-(2,2-difluoroethyl)-3-iodo-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propanenitrile 

Relevant articles and documents

PYRAZOLE COMPOUNDS

The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.