1111645-75-0Relevant academic research and scientific papers
The first enantioselective addition of diethylzinc to aldehydes in ionic liquids catalysed by a recyclable ion-tagged diphenylprolinol
Lombardo, Marco,Chiarucci, Michel,Trombini, Claudio
, p. 11288 - 11291 (2008)
The new procedure for the asymmetric addition of diethylzinc to aryl aldehydes in room-temperature ionic liquids (RTILs) was developed, in the field of chemical synthesis and catalysis. The use of tailored catalysts for metathesis, cross coupling and hydroformylation reactions in RTILs was also explored. A solution of diethylzinc was added to a solution of catalyst 1d and the mixture was stirred at RT for 5 min. The reaction was quenched with a few drops of water and resulting mixture was directly on the top of a silica gel column diluting with CH2Cl2. The results showed that the diphenylprolinol-derived 1d is a promising candidate to accelerate the asymmetric addition of diethylzinc to aromatic aldehydes. This also showed that operation is simple and efficient and is easily recyclable, making use of 10 mol% loading of 1d.
