1111662-34-0Relevant academic research and scientific papers
Copper(I)-catalyzed direct arylation of 1,4-disubstituted 1,2,3-triazoles with aryl iodides
Fukuzawa, Shin-ichi,Shimizu, Eiji,Ogata, Kenichi
scheme or table, p. 645 - 655 (2009/06/08)
Treatment of 1,4-disubstituted 1,2,3-triazoles with aryl iodides in the presence of a catalytic amount of copper chloride and lithium tert-butoxide (stoichiometric) in DMF at 140 °C leads to arylation at the 5-position. Various combinations of substituted
Palladium-catalyzed direct arylations of 1,2,3-triazoles with aryl chlorides using conventional heating
Ackermann, Lutz,Vicente, Ruben,Born, Robert
supporting information; experimental part, p. 741 - 748 (2009/04/10)
Generally applicable, palladium-catalyzed direct arylations of 1,2,3-triazoles with aryl chlorides were accomplished through conventional heating at reaction temperatures of 105-120°C. Thereby, intra- and intermolecular C-H bond functionalizations were achieved with a variety of differently substituted chlorides as electrophiles, bearing numerous valuable functional groups.
