111184-88-4Relevant academic research and scientific papers
Utility of an Inverse-Matrix Technique in the Fast Atom Bombardment Mass Spectrometry-Based Structural Determination of 2-Substituted 1,3-Bis(benzotriazolyl)isoindolines
Isa, Kimio,Takahashi, Ichiro,Tsuzuki, Mikio,Yokota, Hiroshi,Kitajima, Hidehiko
, p. 2403 - 2406 (1994)
Molecular ions (M+'s) of reactive synthetic intermediates (1,3-bis(benzotriazolyl)isoindolines) can be monitored with certainty through a new sample-sorting technique in the fast atom bombardment mass spectrometry (FABMS).
Preparation of 2-substituted 1,3-bis(benzotriazol-1-yl)isoindolines by the double mannich conden-sation reaction of o-phthalaldehyde with primary amines in the presence of 1,2,3-1 h-benzotriazole
Takahashi, Ichiro,Tsuzuki, Mikio,Yokota, Hiroshi,Morita, Toshio,Kitajima, Hidehiko,Isa, Kimio
, p. 71 - 90 (2007/10/02)
The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed aminals is investigated. In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.
The Chemistry of Benzotriazole. Part 3. The Aminoalkylation of Benzotriazole
Katritzky, Alan R.,Rachwal, Stanislaw,Rachwal, Bogumila
, p. 799 - 804 (2007/10/02)
1-(1-Hydroxyalkyl)benzotriazoles convert a wide variety of aromatic and heteroaromatic primary amines into their mono N- derivatives in high yield.Aliphatic primary amines frequently give bis-derivatives.Product structure is established by 13C n.m.r.; dangers in the use of 1H n.m.r. to distinguish 1- and 2-substituted benzotriazoles are pointed out.
