111186-10-8

Basic information

• Product Name: 2-(((4-ethylphenyl)amino)methylene)diethyl malonate
• Synonyms: 2-(((4-ethylphenyl)amino)methylene)diethyl malonate
• CAS NO: 111186-10-8
• Molecular Weight: 291.347
• Mol File: 111186-10-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(((4-ethylphenyl)amino)methylene)diethyl malonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(((4-ethylphenyl)amino)methylene)diethyl malonate(111186-10-8)
• EPA Substance Registry System: 2-(((4-ethylphenyl)amino)methylene)diethyl malonate(111186-10-8)

Safety Data

• Hazardous Substances Data: 111186-10-8(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 111185-65-0 ethyl 6-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Relevant articles and documents

PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

Use of 2-[18F]fluoroethylazide for the Staudinger ligation - Preparation and characterisation of GABAA receptor binding 4-quinolones

The labelling reagent 2-[18F]fluoroethylazide was used in a traceless Staudinger ligation. This reaction was employed to obtain the GABAA receptor binding 6-benzyl-4-oxo-1,4-dihydro-quinoline-3- carboxylic acid (2-[18F]flu

4-Quinolone derivatives: High-affinity ligands at the benzodiazepine site of brain GABAA receptors. Synthesis, pharmacology, and pharmacophore modeling

The 3-ethoxycarbonyl-4-quinolone compound 1 has previously been identified via a database search as an interesting lead compound for ligand binding at the benzodiazepine site of GABAA receptors (Kahnberg et al. J. Mol. Graphics Modelling 2004, 23, 253-261). Pharmacophore-guided optimization of this lead compound yielded a number of high-affinity ligands for the benzodiazepine site including compounds 20 and 23-25 displaying sub-nanomolar affinities. A few of the compounds have been tested on the α1β 2γ2S and α3β 2γ2S GABAA receptor subtypes, and two of the compounds (5 and 19) display selectivity for α1-versus α3-containing receptors by a factor of 22 and 27, respectively. This selectivity for α1β2γ2S is in the same range as that for the well-known α1 subunit selective compound zolpidem.