111194-08-2

Upstream product

• 111194-07-1 (3R,4R)-3,4-bis(4-benzyloxy-3-methoxybenzyl)dihydrofuran-2(3H)-one 
• 111266-00-3 (R)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone 
• 100-44-7 benzyl chloride 
• 111266-03-6 (R)-(+)-3-(4-benzyloxy-3-methoxybenzyl)-γ-butyrolactone 
• 72724-00-6 1-(benzyloxy)-4-(bromomethyl)-2-methoxybenzene 

Downstream Products

• 121621-31-6 L_g-threo-1,4-bis-benzoyloxy-2,3-bis-(4-benzoyloxy-3-methoxy-benzyl)-butane 
• 58311-18-5 (2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol 
• 1612227-16-3 (8R,8'R)-3,3'-dimethoxy-4,4',9-liganetriol 
• 1612227-52-7 C₃₄H₃₆O₅ 
• 1612227-51-6 C₃₄H₃₈O₅ 
• 848844-79-1 (8R,8'R)-4,4'-dihydroxy-3,3'-dimethoxylignane-9,9'-diyl diacetate 
• 1612227-22-1 (8R,8'R)-9-(N,N-dimethylamino)-3,3'-dimethoxylignane-4,4'-diol 
• 1612227-21-0 (8R,8'R)-3,3'-dimethoxy-9a,9b,9b-trihomolignane-4,4'-diol 
• 1612227-20-9 (8R,8'R)-3,3'-dimethoxy-9a,9b,9c,9d-tetrahomolignane-4,4'-diol 
• 1612227-19-6 (8R,8'R)-9-fluoro-3,3'-dimethoxy-4,4'-lignanediol 
• 1612227-18-5 (8R,8′R)-3,3',9,-trimethoxy-4,4'-lignanediol 

Relevant academic research and scientific papers

Cytotoxic activity of dietary lignan and its derivatives: Structure-cytotoxic activity relationship of dihydroguaiaretic acid

Cytotoxic activities of synthesized lignan derivatives were estimated by WST-8 reduction assay against HL-60 and HeLa cells to show the structure-activity relationship. The activities of some effective compounds were examined against Colon 26 and Vero cel

Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7′-oxodihydroguaiaretic acid

The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7′-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.

THE SYNTHESES OF (R)-(+)-β-VANILLYL-γ-BUTYROLACTONE AND OF CHIRAL LIGNANS THEREFROM

(R)-(+)-β-vanillyl-γ-butyrolactone was obtained in 4 steps including a resolution, from vanillin and dimethyl succinate, and was used for the total syntheses of 5 naturally occurring and optically active lignans such as (+)-isolariciresinol 20.