111205-03-9

Basic information

• Product Name: 6-(1H-iMidazol-1-yl)nicotinaldehyde
• Synonyms: 6-(1H-iMidazol-1-yl)nicotinaldehyde
• CAS NO: 111205-03-9
• Molecular Formula: C9H7N3O
• Molecular Weight: 173.17138
• Mol File: 111205-03-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136-137.5 °C
• Boiling Point: 386.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 4.08±0.10(Predicted)
• CAS DataBase Reference: 6-(1H-iMidazol-1-yl)nicotinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(1H-iMidazol-1-yl)nicotinaldehyde(111205-03-9)
• EPA Substance Registry System: 6-(1H-iMidazol-1-yl)nicotinaldehyde(111205-03-9)

Safety Data

• Hazardous Substances Data: 111205-03-9(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 677728-92-6 2-fluoro-5-formylpyridine 
• 23100-12-1 6-chloronicotinylaldehyde 
• 149806-06-4 6-bromonicotinaldehyde 

Relevant articles and documents

Four-coordinate N-heterocyclic carbene (NHC) copper(I) complexes bearing functionalized 3-benzyl-1-(pyridyl)-1H-imidazolylidene ligands: Synthesis, photophysical properties and computational study

Seven luminescent copper(I) complexes bearing four-coordinate N-heterocyclic carbene (NHC) ligands with varying electron-withdrawing substituents including –CF3, –CN, –COCH3, and –CHO groups at the pyridine ring part of the carbene are reported in this study. P1-P4 without the methyl group show better light absorption in low-energy region compared with P5-P7 with the methyl group at the α-position of the pyridine ring. The emitting state of all the complexes is regarded as the 3MLCT/3LLCT character. P1-P4 exhibit the emission maximum in the range of 537–547 nm with the photoluminescence quantum yields (PLQY) of 12.7–21.9% in PMMA films and excited state lifetimes (τ) of 14.7–22.6 μs. The emission wavelengths of P5-P7 are blue-shifted to 505–513 nm compared with those of P1-P4, showing the higher PLQY of 38.0–57.3% and longer τ of 36.2–84.8 μs. Theoretical calculations were used to rationalize the photophysical properties.

Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity

The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a medicament such as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Lewy body dementia and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. In the formula (I), each symbol is as described in the attached specification.

Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure

Compounds of the formula STR1 wherein: Het is imidazol-1-yl or 1,2,4-triazol-1-yl; py is 2-, 3-, or 4-pyridyl; R and R2 are H or alkyl; R1 is H, alkyl or vicinal R1 groups from a C--C double bond; and x is 0 or 1; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions including the same for cardiotonic uses and methods of treating congestive heart failure.