1112200-22-2

Upstream product

• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 914220-97-6 2-(2-cyclopropylethynyl)benzaldehyde 

Downstream Products

• 1174271-23-8 5-cyclopropyl-2-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinoline 
• 1367861-32-2 ethyl 2-benzyl-5-cyclopropylpyrazolo[5,1-a]isoquinoline-1-carboxylate 
• 1372206-22-8 ethyl 2-benzoyl-5-cyclopropylpyrazolo[5,1-a]isoquinoline-1-carboxylate 
• 1112200-35-7 C₁₉H₁₇BrN₂O₂S 
• 1383274-39-2 N-(((4-bromo-3-cyclopropylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide 
• 1400687-55-9 2-(4-chlorophenyl)-5-cyclopropylpyrazolo[5,1-a]isoquinoline 
• 1458688-20-4 5-cyclopropyl-1-phenyl-pyrazolo[5,1-a]isoquinoline 
• 1619916-72-1 N-benzyl-N-((5-cyclopropylpyrazolo[5,1-a]isoquinolin-2-yl)methyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

A multi-component reaction of 2-alkynylbenzaldehyde, 4- methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki-Miyaura coupling reaction, leading to the diverse 1-(isoquinolin-1-yl) guanidines.

Synthesis of H-pyrazolo[5,1-a]isoquinolines via copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air are involved.

Efficient generation of biologically active H-pyrazolo[5,1- a]isoquinolines via multicomponent reaction

A highly efficient multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, alcohol, and α,β-unsaturated aldehyde or ketone is disclosed, which generates the diverse H-pyrazolo[5,1-a]isoquinolines in good yields. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity. Preliminary biological assays show that some of these compounds display promising activities as CDC25B inhibitor, TC-PTP inhibitor, and PTP1B inhibitor.