111256-83-8

Usage

Uses

Used in Vitamin D3 Analysis:
4‐[4‐(dimethylamino)phenyl]‐4,5‐dihydro‐3H‐1,2,4‐triazole‐3,5‐dione is used as a derivatization agent for vitamin D3, specifically for the preparation of 25(OH)D3 samples in liquid chromatography-tandem mass spectrometry (LC-MS). It enhances the detection and quantification of vitamin D3 levels in biological samples, providing accurate and reliable results for assessing vitamin D status in various applications.

Upstream product

• 4755-50-4 4-(dimethylamino)benzoyl chloride 
• 70843-95-7 azido(4-(dimethylamino)phenyl)methanone 
• 16315-59-6 N,N-dimethylaminophenyl isocyanate 
• 112667-72-8 1-ethoxycarbonyl-4-(4'-dimethylaminophenyl)semicarbazide 
• 883455-55-8 4‐(4'‐dimethylaminophenyl)‐1,2,4‐triazolidine‐3,5‐dione 

Relevant academic research and scientific papers

A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry

Rationale 25-Hydroxyvitamin D3 [25(OH)D3] is the best-established indicator of vitamin D status. 4-Phenyl-1,2,4-triazoline-3,5- dione (PTAD), a representative Cookson-type reagent, has often been employed for enhancing the sensitivit

TRIAZOLINEDIONE ADDUCT, METHOD FOR PRODUCING TRIAZOLINEDIONE ADDUCT, METHOD FOR PRODUCING ENE COMPOUND, AND METHOD FOR ANALYZING ENE COMPOUND

Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.)

METHOD FOR PRODUCING SOLID TRIAZOLINEDIONE COMPOUND, SOLID TRIAZOLINEDIONE COMPOUND, AND METHOD FOR PRODUCING TRIAZOLINEDIONE COMPOUND

Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazolinedione solution in which a DAPTAD-containing triazolinedione compound is dissolved is brought into contact with a C5-15 hydrocarbon-based poor solvent to obtain a solid triazolinedione compound. Also, a triazolinedione compound is oxidized using an oxidizing agent that does not produce acid as a byproduct to obtain a triazolinedione compound.