111264-84-7

Usage

Type

Steroid hormone
It is a hormone that is similar in structure to natural corticosteroids produced by the body.

Medicinal use

Anti-inflammatory and immunosuppressant
The drug is used to reduce inflammation and suppress the body's immune response.

Common treatments

Asthma, eczema, arthritis, and allergic reactions

Mechanism of action

Reducing the body's natural immune response and decreasing inflammation
The chemical works by modulating the immune system and reducing inflammation to provide relief.

Side effects

Weight gain, increased blood sugar levels, and an increased risk of infection
Various side effects may occur, and the drug should be used with caution.

Supervision

Should only be used under the supervision of a healthcare professional
A medical professional should monitor the use of this drug to ensure its safety and effectiveness.

Upstream product

• 83-43-2 Methylprednisolone 
• 1968-76-9 21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one 
• 53-36-1 methylprednisolone acetate 
• 1968-77-0 6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17⁽²⁰⁾c-trien-21-oic acid methyl ester 
• 3386-04-7 11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one 

Relevant academic research and scientific papers

Radiolytic degradation scheme for 60Co-irradiated corticosteroids

The cobalt 60 radiolytic degradation products have been identified in the following corticosteroids: cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone sodium succinate, isoflupredone acetate, methylprednisolone, methylprednisolone acetate, prednisolone, prednisolone acetate, and prednisone. Two major types of degradation processes have been identified: loss of the corticoid side chain the D-ring to produce the C-17 ketone and conversion of the C-11 alcohol, if present, to the C-11 ketone. Minor degradation products derived from other changes affecting the side chain are also identified in several corticosteroids. These compounds are frequently associated in corticosteroids as process impurities or degradation compounds. No new radiolytic compounds unique to 60Co-irradiation have been found. The majority of corticosteroids have been shown to be stable to 60Co-irradiation. The rates of radiolytic degradation ranged from 0.2 to 1.4%/Mrad.

Synthesis process of methylprednisolone

The invention provides a synthesis process of methylprednisolone. According to the process, glycol, triethyl orthoformate, 21-deoxy cortisone and PTS are used as raw materials; firstly, through ketalreaction, centrifugation, spin-drying and baking, ketal materials are obtained; then, reduction reaction is performed; water is added for water separation; centrifugation, spin-drying and drying are performed to obtain reduzates; next, epoxy reaction, centrifugation and drying are performed to obtain epoxides; through Grignard reaction, water addition for water separation, centrifugation, spin-drying, baking and drying, Grignard materials are obtained; then, through biological fermentation, iodination reaction, centrifugation, filtering, spin-drying, replacement reaction, centrifugation, and spin-drying, a refined product is obtained; finally, through hydrolysis reaction, centrifugation, spin-drying and baking to the constant weight, a finished product is obtained. The synthesis process has the advantages that the yield and the purity of the product are improved; the production cost is reduced.