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111265-76-0

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111265-76-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 111265-76-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,2,6 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 111265-76:
(8*1)+(7*1)+(6*1)+(5*2)+(4*6)+(3*5)+(2*7)+(1*6)=90
90 % 10 = 0
So 111265-76-0 is a valid CAS Registry Number.

111265-76-0Relevant articles and documents

Formation of Six Cyclic 1,N2-Hydroxybromopropanodeoxyguanosine Isomers upon Reaction of 2-Bromoacrolein with 2'-Deoxyguanosine

Meerman, John H.N.,Pearson, Paul G.,Meier, G. Patrick,Nelson, Sidney D.

, p. 30 - 35 (2007/10/02)

As a preliminary study in the investigation of reactions of the genotoxin 2-bromoacrolein (2-BA) with DNA, we treated the aldehyde with 2'-deoxyguanosine (2'-dG).Six isomeric cyclic 1,N2-propano-2'-deoxyguanosine adducts were isolated and characterized by UV, LSIMS, and 1H NMR spectral techniques.The adducts 1a-1d were identified as diastereomeric 3-(2-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-6-hydroxy-7-bromopyrimidopurin-10(3H)-ones.Adducts 2a and 2b were regioisomeric 7-bromo-8-hydroxy diastereomers.At physiological pH (7.4) and temperature (37 deg C), adducts 1a-1d are hydrolyzed to 6,7-dihydroxypropano-2'-de oxyguanosines.These can be transformed to stable 6,7-dihydroxypropanoguanines by removal of the deoxyribose moiety.The resulting bases can be used as standards for further investigations of reactions of 2-BA with DNA.

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