111282-24-7

Basic information

• Product Name: N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT
• Synonyms: N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT;NDSB223;NSC 133331
• CAS NO: 111282-24-7
• Molecular Formula: C8H17NO4S
• Molecular Weight: 223.29
• Product Categories: Detergents;Sulfobetaines;Heterocycles
• Mol File: 111282-24-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300°C
• Appearance: /
• Solubility: DMSO, Water
• CAS DataBase Reference: N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT(111282-24-7)
• EPA Substance Registry System: N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT(111282-24-7)

Safety Data

• Hazardous Substances Data: 111282-24-7(Hazardous Substances Data)

Usage

Description

N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT, also known as NDSB 223, is a nondetergent sulfobetaine that serves as a highly soluble agent for protein solubilization across a wide range of conditions. As a zwitterionic compound, it maintains no net charge in the typical pH range used in biochemistry, which minimizes the risk of protein denaturation.

Uses

Used in Biochemistry:
N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT is used as a protein solubilization agent for maintaining protein stability and preventing denaturation. Its zwitterionic nature over a broad pH range ensures that it does not impart a significant charge, which is beneficial for preserving the native structure and function of proteins during various biochemical processes.
Used in Pharmaceutical and Biotechnology Industries:
In the pharmaceutical and biotechnology sectors, N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT is utilized as a stabilizing agent in the formulation of protein-based drugs and therapeutics. Its ability to solubilize proteins without causing denaturation makes it an ideal candidate for enhancing the stability and efficacy of protein pharmaceuticals.
Used in Research Laboratories:
N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT is employed as a research tool in laboratories for studying protein behavior, interactions, and structure. Its solubilizing properties allow researchers to work with proteins in their native state, facilitating a better understanding of their functions and potential applications in medicine and biotechnology.
Chemical Properties:
N-METHYL-N-(3-SULFOPROPYL)MORPHOLINIUM, INNER SALT is a white solid, which contributes to its stability and ease of handling in various applications.

InChI:InChI=1/C8H17NO4S/c1-9(4-6-13-7-5-9)3-2-8-14(10,11)12/h2-8H2,1H3

Upstream product

• 109-02-4 4-methyl-morpholine 
• 1120-71-4 1,3-propanesultone 

Relevant articles and documents

The influence of bromide-based ionic liquids on solubility of {LiBr (1)?+?water (2)} system. Experimental (solid?+?liquid) phase equilibrium data. Part 2

The main aim of the work is to investigate ionic liquids (ILs) or zwitterionic compound (ZI) as anti-crystallization additives for {LiBr (1) + water (2)} system, conventionally used as a working pair in absorption refrigeration technology. In this study, solubility of lithium bromide in water has been determined at wide temperature and composition range and compared to the literature data. The transition temperature and enthalpy between lithium dihydrate and lithium monohydrate forms were calculated using the van't Hoff plot. The main purpose of this work is to determine and discuss the solubility of lithium bromide in water in presence of IL, or ZI as an additive. The solubility measurements have been carried out using dynamic method within temperature range from (230 to 370) K. In this work, new ILs namely: N-methyl-N-(2-hydroxyethyl)morpholinium bromide, [MOR1,2OH][Br], N-(2-acetyloxy)ethyl-N-methyl-morpholinium bromide, [MOR1,2(OOC)1][Br], N-methyl-N-(2-ethoxy-2-oxoethyl)-morpholinium bromide, [MOR1,1(COO)2][Br], 1-methyl-3-(2-hydroxyethyl)imidazolium bromide, [Im1,2OH][Br], N-methyl-N-(2-hydroxyethyl)-pyrrolidinium bromide, [PYR1,2OH][Br], 2-hydroxyethypyridinium bromide, [Py2OH]Br], N-(2-hydroxy-ethyl)-N,N,N-triethyl-ammonium bromide, [N2,2,2,2OH][Br], N-(cyanomethyl)-N,N,Ntriethylammonium bromide, [N2,2,2,1CN][Br], N-(2-hydroxyethyl)-N,N-dimethyl-N-butyl-ammonium bromide, [N1,1,2OH,4][Br], N,N-di(2-hydroxyethyl)-N,N-dimethylammonium bromide, [N1,1,2OH,2OH][Br] and ZI namely: 3-(1-methylmorpholinium)propane-1-sulfonate, [MOR1,3SO3] were investigated. All compounds have been synthesized and characterized using NMR analysis. The thermophysical characterization of pure compounds, including: temperature of phase transition (Ttr), enthalpy of phase transition (?trH), melting temperature (Tm) and enthalpy of melting (?mH) have been measured using differential scanning calorimetry technique (DSC) at pressure p = 100 kPa. The experimental phase equilibria measurements for {LiBr (1) + IL, or ZI (2) + water (3)} ternary systems, with fixed IL to LiBr mass fraction w = 0.3 for all ILs and w = 0.1 and 0.2 for ammonium-based ILs and [MOR1,3SO3] have been performed by dynamic method. For all of the tested systems the transition point between lithium bromide dihydrate and monohydrate form was observed. Significant solubility enhancement of lithium bromide in water was obtained by adding ionic liquid, or zwitterionic compound to the lithium bromide + water solution. The experiment shows, that the greatest increase in solubility of LiBr in water was observed when [MOR1,3SO3], or [N1,1,2OH,2OH][Br] were added. This work is the first step of the experimental work in this area and further research will be carried out.

Separation of olefin/paraffin mixtures using zwitterionic silver complexes as transport carriers

Zwitterionic silver nitrate salts of 1-(1-melhyl-3-imidazolio)pro-pane-3- sulfonate, 1-(1-methyl-1-pyrrolidinio)propane-3-sulfonate, and 1-(4methyl-4-morpholio)propane-3-sulfonate have been prepared and tested as carriers for facilitated olefin transport membranes in the separation of ethylene/ethane, propylene/propane, and C4 mixtures. The interactions of olefins with silver ions hound to sulfonate groups were investigated by FTIR spectroscopy as well as the correlation between the binding affinity of olefins and facilitated transport.