111304-31-5

Basic information

• Product Name: nifedipine iMpurity C
• Synonyms: nifedipine iMpurity C;Nifedipine impurity C (EP);APKKCRAKPMSAEI-YFHOEESVSA-N
• CAS NO: 111304-31-5
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 374.38778
• Mol File: 111304-31-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 90-93 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 395.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3(Predicted)
• CAS DataBase Reference: nifedipine iMpurity C(CAS DataBase Reference)
• NIST Chemistry Reference: nifedipine iMpurity C(111304-31-5)
• EPA Substance Registry System: nifedipine iMpurity C(111304-31-5)

Safety Data

• Hazardous Substances Data: 111304-31-5(Hazardous Substances Data)

Usage

Uses

Methyl 2-[(2-nitrophenyl)methylidene]-3-oxobutanoate is an impurity compound of Nifedipine (N457000). Nifedipine is an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker.

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 552-89-6 2-nitro-benzaldehyde 
• 75-05-8 acetonitrile 

Downstream Products

• 126126-78-1 5-Cyano-2-hydroxy-2-methyl-4-(2-nitro-phenyl)-6-pyrrolidin-1-yl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid methyl ester 
• 52508-63-1 2-pyrrolidino-6-methyl-4-(2-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester 
• 63675-72-9 nisoldipine 
• 126126-82-7 5-Cyano-2-methyl-4-(2-nitro-phenyl)-6-pyrrolidin-1-yl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 126126-81-6 5-Cyano-6-diethylamino-2-methyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester 
• 126412-02-0 1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(2-nitrophenyl)-5-oxo-chinolin-3-methylat 
• 39562-82-8 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester-5-isopropyl ester 
• 67587-23-9 methyl 5-cyano-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 
• 119746-86-0 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethyl} ester 5-methyl ester 
• 136814-27-2 tert-butyl 7-(2-nitrophenyl)-5,8a-dimethyl-8-methoxycarbonyl-2,3,7,8-tetrahydro-7H-oxazolo<3,2-a>pyridin-6-carboxylate 
• 126126-77-0 5-Cyano-6-diethylamino-2-hydroxy-2-methyl-4-(2-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

Cross-linked polystyrene-TiCl4 complex as a reusable Lewis acid catalyst for solvent-free Knoevenagel condensations of 1,3-dicarbonyl compounds with aldehydes

Cross-linked polystyrene copolymer beads with the average particle size in the range of (50–80 mesh size) were prepared by a new method, characterized and functionalized with titanium tetrachloride to afford the corresponding polystyrene?titanium tetrachloride complex in one step reaction and characterized by FT-IR, UV, TGA, DSC, XRD, SEM, BET. This polymer metal complex (PS/TiCl4) was used as a heterogeneous, recoverable, reusable Lewis acid for solvent-free Knoevenagel condensations of 1,3-diketones with aromatic aldehydes under green and mild conditions. The rate of reactions was found to decrease with an increasing percentage of crosslinking and the mesh size of the copolymer beads. This complex showed good stability and catalytic activity in the Knoevenagel reactions.

AN IMPROVED PROCESS FOR THE PREPARATION OF PURE NISOLDIPINE

Nisoldipine is prepared by the process according to this invention by cyclocondensing 3-Aminocrotonoic acid isobutyl ester with 2-(2-nitrobenzylidene)-3-oxo-butyric acid methyl ester in the presence of a water immiscible organic solvent such as toluene and an aprotic organic solvent. The reaction product is recovered after refluxing with diisopropyl ether. Water miscible aprotic solvent may be selected from ethers and glycol ethers.

Electrochemical Behaviour of an Unsymmetrical 4-(o-Nitrophenyl)-1,4-Dihydropyridine in Protic Medium.

The electrochemical behaviour of 3-cyano-5-methoxycarbonyl-2,6-dimethyl-4(o-nitrophenyl)-1,4-dihydropyridine and the corresponding N-methyl derivative have been investigated in hydroalcoolic medium.The 4 electron reduction leads to an amino-benzonaphtyrid