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1113041-80-7

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1113041-80-7 Usage

Description

(S)-1-(2-nitrophenyl)ethanamine (Hydrochloride), also known as 2-Nitroamphetamine, is a psychoactive chemical compound belonging to the phenethylamine and amphetamine classes. With the molecular formula C8H10ClNO2, it is recognized for its stimulant properties and potential effects on the central nervous system, influencing mood, cognition, and behavior. Despite its research applications, it is not approved for medical or recreational use due to concerns regarding its potential for abuse and dependence.

Uses

Used in Research Applications:
(S)-1-(2-nitrophenyl)ethanamine (Hydrochloride) is utilized as a research chemical for studying its effects on the central nervous system. It aids in understanding the mechanisms of action and potential applications in neuroscience and psychopharmacology.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (S)-1-(2-nitrophenyl)ethanamine (Hydrochloride) serves as a compound of interest for the development of new drugs targeting the central nervous system. Its properties may contribute to the creation of medications for various neurological and psychiatric disorders, although further research is required to ensure safety and efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 1113041-80-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,3,0,4 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1113041-80:
(9*1)+(8*1)+(7*1)+(6*3)+(5*0)+(4*4)+(3*1)+(2*8)+(1*0)=77
77 % 10 = 7
So 1113041-80-7 is a valid CAS Registry Number.

1113041-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S)-1-(2-nitrophenyl)ethanamine,hydrochloride

1.2 Other means of identification

Product number -
Other names (S)-1-(2-Nitrophenyl)ethanamine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1113041-80-7 SDS

1113041-80-7Downstream Products

1113041-80-7Relevant articles and documents

Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through Monomer Position and Functionality

Fowler, Sarah A.,Luechapanichkul, Rinrada,Blackwell, Helen E.

experimental part, p. 1440 - 1449 (2009/07/30)

N-Substituted glycine oligomers, or peptoids, have emerged as an important class of foldamers for the study of biomolecular interactions and for potential use as therapeutic agents. However, the design of peptoids with well-defined conformations a priori remains a formidable challenge. New approaches are required to address this problem, and the systematic study of the role of individual monomer units in the global peptoid folding process represents one strategy. Here, we report our efforts toward this approach through the design, synthesis, and characterization of peptoids containing nitroaromatic monomer units. This work required the synthesis of a new chiral amine building block, (S)-1-(2-nitrophenyl)ethanamine (s2ne), which could be readily installed into peptoids using standard solid-phase peptoid synthesis techniques. We designed a series of peptoid nonamers that allowed us to probe the effects of this relatively electron-deficient and sterically encumbered a-chiral side chain on peptoid structure, namely, the peptoid threaded loop and helix. Circular dichroism spectroscopy of the peptoids revealed that the nitroaromatic monomer has a significant effect on peptoid secondary structure. Specifically, the threaded loop structure was disrupted in a nonamer containing alternating V-(S)-1-phenylethylglycine (VVspe) and VVs2ne monomers, and the major conformation was helical instead. Indeed, placement of a single Ns2ne at the N-terminal position of (VVspe)9 resulted in a destabilized form of the threaded loop structure relative to the homononamer (VVspe)9. Conversely, we observed that incorporation of V-(S)-1-(4-nitrophenyl)ethylglycine (VVsnp, a p-nitro monomer) at the VV-terminal position stabilized the threaded loop structure relative to (VVspe)9. Additional experiments revealed that nitroaromatic side chains can influence peptoid nonamer folding by modulating the strength of key intramolecular hydrogen bonds in the peptoid threaded loop structure. Steric interactions were also implicated for the VVs2ne monomer. Overall, this study provides further evidence that aromatic side-chain structure, even if perturbed in a single monomer unit, can strongly influence local peptoid backbone conformation.

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