111321-67-6

Basic information

• Product Name: Dihydroxy Oxaliplatin-Pt(IV)
• Synonyms: Dihydroxy Oxaliplatin-Pt(IV);(OC-6-33)-[(1R,2R)-1,2-CyclohexanediaMine-κN1,κN2][ethanedioato(2-)-κO1,κO2]dihydroxyplatinuM;[OC-6-33-(1R-trans)]-(1,2-CyclohexanediaMine-N,N') [ethanedioato(2-)-O,O']dihydroxyplatinuM;(OC-6-33)-[(1R,2R)-Cyclohexane-1,2-diamine-κN,κN′][ethanedioato(2-)-κO1,κO2]dihydroxyplatinum
• CAS NO: 111321-67-6
• Molecular Formula: C₈H₁₆N₂O₆Pt
• Molecular Weight: 429.28456
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 111321-67-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Water (Slightly)
• CAS DataBase Reference: Dihydroxy Oxaliplatin-Pt(IV)(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydroxy Oxaliplatin-Pt(IV)(111321-67-6)
• EPA Substance Registry System: Dihydroxy Oxaliplatin-Pt(IV)(111321-67-6)

Safety Data

• RIDADR: UN 3467 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 111321-67-6(Hazardous Substances Data)

Usage

Uses

An Oxaliplatin (O845075) derivative. An orally active antitumor cyclohexanediamine-Pt(IV) complex. Oxaliplatin impurity C as per EP.

Upstream product

• 7722-84-1 dihydrogen peroxide 
• 61825-94-3 Oxaliplatin 
• 141610-50-6 oxaliplatin 
• 61825-94-3 oxaliplatin 

Relevant articles and documents

Preparation method and application of compounds and anticancer drugs

The invention provides compounds, which are twin drugs formed by a platinum drug and a small molecule drug covalently connected to the axial position of the platinum drug and having an immune negative modulation relieving function, and have structures as shown in a formula I: wherein the structure of the platinum drug is in a dotted frame; R1 and R2 are the same or different small molecule drugs with the function of relieving immune negative regulation; or one of R1 and R2 is a small molecule medicine with an immune negative regulation relieving function, and the other one is hydroxyl. According to the invention, the small molecule drug with the function of relieving the negative immune regulation is covalently linked to the axial position of the platinum drug to form the twin drug, so that the tumor killing effect of the platinum drug and the function of relieving the negative immune regulation of the small molecule drug are simultaneously exerted at the tumor site; the twin drugs are combined with immunotherapy for use, so that the response of immunotherapy can be effectively improved, and the treatment effect on tumors is remarkably improved. The platinum anticancer twin drug are simple in preparation method, low in cost and suitable for industrial production, and has clinical transformation potential.

Compound having asymmetric mono-substituted coumarin tetravalent platinum structure, preparation method thereof and use thereof in preparation of antitumor drugs

A compound having an asymmetric mono-substituted coumarin tetravalent platinum structure has a structural formula as shown in the description. A preparation method of the compound having an asymmetricmono-substituted coumarin tetravalent platinum structure specifically comprises the following steps: adding TBTU and a coumarin derivative to a reaction container, replacing air in the system with nitrogen, adding dried DMF for stirred reaction for about 10 minutes at room temperature, adding dried triethylamine to the reaction system for stirred reaction for about 10 minutes at room temperature,finally adding a tetravalent platinum compound to the reaction system, replacing air in the flask with N2 and putting the reaction system at 25-120 DEG C for light-shielded reaction for 12-72 hours,removing the solvent under reduced pressure, and carrying out column chromatography to obtain an asymmetric mono-substituted coumarin modified tetravalent platinum compound having the general formula(1).

Carbonic anhydrase-targeted Pt (IV) complex, preparation method and application thereof

The invention discloses a carbonic anhydrase (CAIX) targeted Pt (IV) complex as well as a preparation method and application thereof. The invention firstly provides the CAIX-targeted Pt (IV) complex which has the targeting characteristic of CAIX, can specifically identify tumor cells, effectively inhibit the activity of CAIX, is non-toxic to normal cells, enhances the toxicity under the conditionof anoxia, and has remarkable antitumor activity. Compared with a Pt (II) drug, the complex has the characteristics of improving tumor selectivity, reducing liver injury, reducing renal toxicity and having no toxic or side effect, and can be specifically combined with an anti-tumor target, so that the sensitivity of the platinum drug in a hypoxia environment is improved. The invention also provides a preparation method of the complex, which comprises the following steps of: mixing CAIXi and Pt (IV) - COOHx in a DMF solution containing N,N-diisopropylethylamine, and carrying out condensation reaction to obtain the complex. The preparation method is simple and low in cost. The product has a good antitumor drug application prospect and a wide development space.