111392-91-7

Upstream product

• 2381-87-5 4-methyl-5,6-dihydro-2H-pyran-2-one 
• 95496-33-6 (R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-pentane-1,3-diol 
• 3277-89-2 phenethylmagnesium bromide 
• 111392-90-6 (S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-3-methyl-pentanal 

Downstream Products

• 111392-93-9 Acetic acid (S)-3,5-dihydroxy-3-methyl-1-phenethyl-pentyl ester 
• 111466-31-0 (4R,6R)-4-Hydroxy-4-methyl-6-phenethyl-tetrahydro-pyran-2-one 
• 111466-33-2 (4R,6S)-4-Hydroxy-4-methyl-6-phenethyl-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

STUDIES ON ASYMMETRIC SYNTHESIS OF β-HYDROXY-δ-LACTONE INHIBITORS OF HMGCoA REDUCTASE 1. A NEW PREPARATION OF THE LACTONE MOIETY OF COMPACTIN

A new strategy for the preparation of chiral β-hydroxy-δ-lactone inhibitors of HMGCoA reductase is outlined: in particular the compactin lactone moiety has been elaborated by asymmetric epoxidation of the appropriate allylic alcohol and subsequent introdu