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Combretastatin A-3 is a naturally occurring stilbenoid compound derived from the African tree Combretum caffrum. It is recognized for its antineoplastic properties and has been extensively studied for its potential in cancer treatment. Combretastatin A-3 primarily functions by inhibiting angiogenesis, the process of new blood vessel formation, thereby restricting the growth and metastasis of tumors. It demonstrates significant cytotoxicity towards vascular endothelial cells and has been considered for the treatment of age-related macular degeneration.

111394-45-7

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111394-45-7 Usage

Uses

Used in Medical Industry:
Combretastatin A-3 is used as a lead compound for the development of various drugs targeting cancer treatment. Its ability to disrupt angiogenesis makes it a promising candidate for the creation of anti-cancer agents.
Combretastatin A-3 is used as a potential treatment for age-related macular degeneration due to its effects on inhibiting the formation of new blood vessels in the eye.
In Cancer Treatment:
Combretastatin A-3 is used as an antineoplastic agent for its high cytotoxicity towards vascular endothelial cells, which helps in restricting the growth and spread of tumors.
In Drug Development:
Combretastatin A-3 serves as a foundational component in the development of drugs like combretastatin A-4 phosphate, which has been advanced to clinical trials for the treatment of various types of cancer. Its role in drug development is crucial for creating novel therapeutics that can effectively target and combat cancerous cells.

Check Digit Verification of cas no

The CAS Registry Mumber 111394-45-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,3,9 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 111394-45:
(8*1)+(7*1)+(6*1)+(5*3)+(4*9)+(3*4)+(2*4)+(1*5)=97
97 % 10 = 7
So 111394-45-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H18O5/c1-20-15-7-6-11(8-13(15)18)4-5-12-9-14(19)17(22-3)16(10-12)21-2/h4-10,18-19H,1-3H3/b5-4-

111394-45-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[(Z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-2,3-dimethoxyphenol

1.2 Other means of identification

Product number -
Other names combretastatins A-3

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:111394-45-7 SDS

111394-45-7Synthetic route

3,3'-bis-(tert-butyldimethylsilyloxy)-4',4,5-trimethoxy-(Z)-stilbene
111394-58-2

3,3'-bis-(tert-butyldimethylsilyloxy)-4',4,5-trimethoxy-(Z)-stilbene

combretastatin A-3
111394-45-7

combretastatin A-3

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran91%
acetic anhydride
108-24-7

acetic anhydride

combretastatin A-3
111394-45-7

combretastatin A-3

combretastatin A-3 diacetate
111394-48-0

combretastatin A-3 diacetate

Conditions
ConditionsYield
With pyridine for 72h; Ambient temperature;
combretastatin A-3
111394-45-7

combretastatin A-3

combretastatin B2
111394-46-8

combretastatin B2

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol Ambient temperature;

111394-45-7Relevant academic research and scientific papers

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