11140-67-3

Basic information

• Product Name: syringomycin
• Synonyms: syringomycin;N-[3-(Hydroxy)dodecanoyl]cyclo(L-Ser-D-Ser-L-A2bu-D-A2bu-L-Arg-L-Phe-[(Z)-2-amino*-3-hydroxy-2-butenoyl]-[(3S)-3-hydroxy-L-Asp-]-4-chloro-L-Thr-)
• CAS NO: 11140-67-3
• Molecular Weight: 0
• Mol File: 11140-67-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: syringomycin(CAS DataBase Reference)
• NIST Chemistry Reference: syringomycin(11140-67-3)
• EPA Substance Registry System: syringomycin(11140-67-3)

Safety Data

• Hazardous Substances Data: 11140-67-3(Hazardous Substances Data)

Usage

General Description

Syringomycin is a family of lipodepsipeptide antibiotics produced by certain strains of the bacterium Pseudomonas syringae. These molecules exhibit a wide range of biological activities, including antimicrobial and antifungal properties. Syringomycin is known for its ability to disrupt the cell membranes of target microorganisms, leading to their destruction. It has also been shown to have potential applications in agriculture for controlling plant pathogens and in medicine for treating infections. Syringomycin has drawn significant interest for its unique chemical structure and potent bioactivity, making it a valuable and versatile tool in various fields of research and application.

Related news

Requirement of sphingolipid α-hydroxylation for fungicidal action of syringomycin (cas 11140-67-3) E07/27/2019

Syringomycin E is an antifungal cyclic lipodepsinonapeptide produced by Pseudomonas syringae pv. syringae. To understand the mechanism of action of syringomycin E, a novel resistant Saccharomyces cerevisiae strain, BW7, was isolated and characterized. Lipid analyses revealed that BW7 contained o...detailed

The effect of sterols on the sensitivity of membranes to the channel-forming antifungal antibiotic, syringomycin (cas 11140-67-3) E07/25/2019

The ability of three sterols of different structure to influence the interaction of syringomycin E (an antifungal antibiotic that forms voltage dependent channels in planar lipid bilayers) with a planar lipid bilayer was evaluated. The rate of increase of bilayer conductance induced by syringomy...detailed

Role of ergosterol in growth inhibition of Saccharomyces cerevisiae by syringomycin (cas 11140-67-3) E07/23/2019

The antifungal activity of the lipodepsipeptide syringomycin E from Pseudomonas syringae pv. syringae is modulated by sterols. To study the requirement of the predominant fungal sterol, ergosterol, in syringomycin E action, the sterol composition of Saccharomyces cerevisiae sterol auxotroph stra...detailed

Channel-forming activity of syringomycin (cas 11140-67-3) E in two mercury-supported biomimetic membranes07/22/2019

The lipodepsipeptide syringomycin E (SR-E) interacts with two mercury-supported biomimetic membranes, which consist of a self-assembled phospholipid monolayer (SAM) and of a tethered bilayer lipid membrane (tBLM) separated from the mercury surface by a hydrophilic tetraethyleneoxy (TEO) spacer t...detailed

Structure of the lipodepsipeptide syringomycin (cas 11140-67-3) E in phospholipids and sodium dodecylsulphate micelle studied by circular dichroism, NMR spectroscopy and molecular dynamics07/20/2019

Syringomycin E (SRE) is a member of a family of lipodepsipeptides that characterize the secondary metabolism of the plant-associated bacteria Pseudomonas syringae pv. syringae. It displays phytotoxic, antifungal and haemolytic activities, due to the membrane interaction and ion channel formation...detailed

Lipid-mediated regulation of pore-forming activity of syringomycin (cas 11140-67-3) E by thyroid hormones and xanthene dyes07/21/2019

The effects of dipole modifiers, thyroid hormones (thyroxine and triiodothyronine) and xanthene dyes (Rose Bengal, phloxineB, erythrosin, eosinY and fluorescein) on the pore-forming activity of the lipopeptide syringomycin E (SRE) produced by Pseudomonas syringae were studied in a model bilayer....detailed