111422-87-8

Upstream product

• 103-71-9 phenyl isocyanate 
• 5414-21-1 5-bromopentan-1-nitrile 
• 57050-07-4 2-phenyl-3,4,5,6-tetrahydropyridine 
• 591-51-5 phenyllithium 
• 3466-80-6 2-phenylpiperidine 
• 111422-83-4 2-Phenyl-piperidine-1-carboxylic acid phenylamide 

Relevant academic research and scientific papers

2,2- and 2,6-diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines

2-Aryltetrahydropyridines formed by anionic cyclization or ring-closing metathesis were converted to their N′-aryl urea derivatives. Depending on the position of the unsaturation within the tetrahydropyridine ring, metalation by deprotonative lithiation or carbolithiation led to migration of the N′-aryl substituent to the 2- or 6-position via intramolecular nucleophilic attack of a benzylic organolithium on the aryl ring. The products are a range of 2,2-, 2,2,3-, and 2,6-polysubstituted piperidine derivatives. Related chemistry was observed in pyrroline homologues.

Oxidation of N-Acyl-Pyrrolidines and -Piperidines with Iron(II)-Hydrogen Peroxide and an Iron Complex-Molecular Oxygen

The reactions of N-acyl-pyrrolidines (1a-c) and -piperidines (1d-f) with Fe(II)-hydrogen peroxide in aqueous 95percent acetonitrile gave the corresponding pyrrolidin-2-ones (2a-c) and piperidin-2-ones (2d-f).The lactams (2a-f) were also the products in the oxidation of (1a-f) with molecular oxygen in the presence of an iron complex, either or , in aqueous 90percent pyridine.