1114235-31-2Relevant academic research and scientific papers
A new approach to the benzopyridoxepine core by metal mediated intramolecular biaryl ether formation
Serban, Georgeta,Abe, Hitoshi,Takeuchi, Yasuo,Harayama, Takashi
experimental part, p. 2949 - 2958 (2009/05/31)
This paper presents a concise synthesis of the novel [1,3]dioxo[d]benzoxepino[2,3-c]-6-bromopyridine 1. The benzopyridoxepine core has been obtained by intramolecular coupling of a benzopyridylethene that is in turn obtained from the Wittig reaction. Thus, the synthesis was accomplished in a very good yield by implementation of an intramolecular palladium-catalyzed biaryl ether formation (Buchwald-Hartwig type reaction). An alternative approach based on the copper-mediated C-O bond formation (intramolecular Ullmann reaction) was not successful.
