111424-46-5

Upstream product

• 110-89-4 piperidine 
• 696-63-9 4-Methoxybenzenethiol 
• 541-47-9 3-Methylbutenoic acid 

Downstream Products

• 229961-87-9 3-(4-methoxy-phenylsulfanyl)-3-methyl-butyric acid chloride 
• 229961-22-2 ethyl 4-<(2,2-dimethyl-4-oxo-thiochroman-6-yl)ethynyl>benzoate 
• 229961-35-7 ethyl 4-<(2,2-dimethyl-4-oxothiochroman-6-yl)ethynyl>-2-fluorobenzoate 
• 229961-24-4 ethyl 4-<<4-phenyl-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-30-2 ethyl 4-<<4-(5-methyl-thiophen-2-yl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-33-5 ethyl 4-<<4-(6-methyl-pyridin-3-yl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-41-5 ethyl 6-<<4-(4-methylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>-ethynyl>-nicotinate 
• 229961-45-9 VTP 194310 
• 229961-26-6 ethyl 4-<<4-(4-methylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-31-3 ethyl 4-<<4-(5-ethyl-thiophen-2-yl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-27-7 ethyl 4-<<4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 
• 229961-42-6 ethyl 6-<<4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>-ethynyl>-nicotinate 
• 229961-28-8 ethyl 4-<<4-(4-isopropylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl>ethynyl>-benzoate 

Relevant academic research and scientific papers

EXPANSION OF RENEWABLE STEM CELL POPULATIONS

Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.

METHODS FOR TREATING CHEMOTHERAPY AND RADIATION THERAPY SIDE EFFECTS

A method for treating chemo therapy or radiation therapy side effects in a mammal undergoing chemotherapy and/or radiation therapy, the method comprising a step of administering to the mammal a therapeutically effective amount of a RAR antagonist or RAR i

Methods of treatment during vascular procedures

The invention provides in one embodiment a method for treating vascular trauma. The method can include administering to an individual undergoing vascular trauma an effective amount of a retinoic acid receptor (RAR) antagonist or an RAR inhibitor. The meth

Methods of treating hyperlipidemia

The current invention relates to methods for treating hyperlipidemia in mammals, including humans. More specifically, the current invention relates to the use of retinoid or retinoid derivative that is able to act as an antagonist or inverse agonist of a

Synthesis and biological activity of high-affinity retinoic acid receptor antagonists

This article reports the synthesis and biological activity of new high affinity retinioic acid receptor (RAR) antagonists. The effect of introducing heteroatoms in the bicyclic ring system of the potent dihydronaphthalene RAR antagonist 8, and the variation of the pendant aromatic group on the ability of these compounds to function as RAR antagonists is discussed. The use of binding, transcriptional, and in vivo assays revealed that the 2,2-dimethylthiochromene analogue 59, and the 2,2-dimethylchromene derivative 85, were the most effective in blocking retinoid agonist induced activity. Copyright (C) 1999 Elsevier Science Ltd.

Synthesis of 2,2-Dimethyl-2H-thiochromenes, the Sulfur Analogs of Precocenes

A new general synthesis of 2,2-dimethyl-2H-thiochromenes in good yield consists of the Michael addition of thiophenols to 3-methyl-2-butenoic acid, intramolecular cyclocondensation of the resultant 3-methyl-3-phenylthiobutanoic acids, reduction of the 2,2-dimethyl-4-oxothiochromenes thus obtained with sodium borohydride, and acid-catalyzed dehydration of the resultant 4-hydroxy-2,2-dimethylthiochromans.