111437-47-9

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 5862-49-7 2-(isopropylthio)ethyl acetate 

Downstream Products

• 121045-25-8 ethyl 4-hydroxy-2-<2-hydroxy-1-(isopropylthio)ethyl>benzoate 
• 121045-55-4 3-(1,2-Bis-isopropylsulfanyl-ethyl)-4-hydroxy-benzoic acid propyl ester 
• 121045-54-3 3-(1,2-Bis-isopropylsulfanyl-ethyl)-4-hydroxy-benzoic acid ethyl ester 
• 121045-52-1 4-Hydroxy-3-(2-isopropylsulfanyl-1-methoxy-ethyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

SELECTIVE PREPARATION AND CYCLIZATION OF 2-(2-HYDROXYPHENYL)-2-(ISOPROPYLTHIO)ETHANOLS. NEW SYNTHESIS OF 1-BENZOFURANS

Reaction of phenols with 2-(isopropylthio)ethyl acetate activated by sulphuryl chloride afforded 2-phenols regioselectively, via sigmatropic rearrangement of phenoxysulphonium ylides.The ortho-alkylated phenols thus obtained have been cyclized with conc. hydrochloric acid in 2-methoxyethanol to 1-benzofurans. 2-Methyl- and 2-phenyl-1-benzofurans have been prepared similarly.

Improved General Method of Ortho Alkylation of Phenols Using Alkyl Isopropyl Sulfide, Sulfuryl Chloride and Triethylamine. An Expedient Synthesis of Representative Oxygen Heterocycles and (2R,4'R,8'R)-α-Tocopherol

Functionalized alkyl groups have been introduced regioselectively into the ortho position of phenols via sigmatropic rearrangement of isopropylphenoxysulfonium alkylide, providing a quite efficient synthesis of precursors for chromans, chromens, coumarins, and d-α-tocopherol.