1114427-40-5

Basic information

• Product Name: 4-bromo-3,5,6-trifluoro-N-{[4-(methyloxy)phenyl]methyl}-2-pyridinamine
• Synonyms: 4-bromo-3,5,6-trifluoro-N-{[4-(methyloxy)phenyl]methyl}-2-pyridinamine
• CAS NO: 1114427-40-5
• Molecular Weight: 347.134
• Mol File: 1114427-40-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-3,5,6-trifluoro-N-{[4-(methyloxy)phenyl]methyl}-2-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-3,5,6-trifluoro-N-{[4-(methyloxy)phenyl]methyl}-2-pyridinamine(1114427-40-5)
• EPA Substance Registry System: 4-bromo-3,5,6-trifluoro-N-{[4-(methyloxy)phenyl]methyl}-2-pyridinamine(1114427-40-5)

Safety Data

• Hazardous Substances Data: 1114427-40-5(Hazardous Substances Data)

Upstream product

• 3511-90-8 4-bromo-2,3,5,6-tetrafluoropyridine 
• 2393-23-9 4-methoxy-benzylamine 

Relevant articles and documents

Synthetic utility of 4-bromo-2,3,5,6-tetrafluoropyridine

The regiochemistry of nucleophilic substitution of 4-bromo-2,3,5,6-tetrafluoropyridine has been investigated. Efficient, regioselective reactions occur with alkylamine, benzylamine and alkoxide nucleophiles, yielding products where substitution occurs ortho to the ring nitrogen. The resulting 2-substituted-4-bromo-3,5,6-trifluoropyridines can be functionalised further, either by a second regioselective nucleophilic displacement or palladium catalysed elaboration at the 4-position. Reactions with aromatic N-nucleophiles yield mixtures of ortho- and para-substituted products.