111447-52-0

Upstream product

• 16872-09-6 1,2-dicarba-closo-dodecaborane⁽¹²⁾ 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 696-62-8 para-iodoanisole 
• 66068-56-2 1-MgCl-1.2-C₂B₁₀H₁₁ 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 17702-41-9 nido-decaborane 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1427080-85-0 C₁₀H₂₀B₁₀O 
• 1427081-57-9 1-(4-methoxyphenyl)-2-ethyl-1,2-dicarba-closo-dodecaborane 
• 1427082-19-6 C₁₃H₂₆B₁₀O 
• 1427082-95-8 C₁₃H₂₆B₁₀O 

Relevant academic research and scientific papers

Light-promoted copper-catalyzed cage C-Arylation of: O-carboranes: facile synthesis of 1-Aryl-o-carboranes and o-carborane-fused cyclics

Light-promoted, copper catalyzed cage C-H arylation of o-carboranes with aryl halides has been achieved, leading to the facile synthesis of a variety of 1-Aryl-o-carboranes and o-carborane-fused cyclics. This method has the following features: (1) using o

Preparation of dendritic carboranyl glycoconjugates as potential anticancer therapeutics

A series of carborane-appended glycoconjugates containing three and six glucose and galactose moieties have been synthesizedviaCu(i)-catalyzed azide-alkyne [3 + 2] click cycloaddition reaction. The carboranyl glycoconjugates containing three glucose and g

Palladium-Catalyzed Direct Cross-Coupling of Carboranyllithium with (Hetero)Aryl Halides

A palladium-catalyzed direct C-arylation reaction of readily available cage carboranyllithium reagents with aryl halides has been developed for the first time. This method is applicable to a wide range of aryl halide substrates including aryl iodides, aryl bromides, and heteroaromatic halides.

Nickel-catalyzed cross-coupling reactions of o-carboranyl with aryl iodides: Facile synthesis of 1-aryl-o-carboranes and 1,2-diaryl-o-carboranes

A nickel-catalyzed arylation at the carbon center of o-carborane cages has been developed, thus leading to the preparation of a series of 1-aryl-o-carboranes and 1,2-diaryl-o-carboranes in high yields upon isolation. This method represents the first examp

Development of hypoxia-inducible factor (HIF)-1α inhibitors: Effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia

A series of substituted ortho-carboranylphenoxyacetanilides were synthesized and evaluated for their ability to inhibit hypoxia-induced HIF-1 transcriptional activity using a cell-based reporter assay in HeLa cells expressing the HRE-dependent firefly luciferase reporter construct (HRE-Luc) and constitutively expressing CMV-driven Renilla luciferase reporter, and their ability to inhibit cell growth (GI50) using the MTT assay. Among the compounds synthesized, 1g and 1l showed significant inhibition of hypoxia-induced HIF-1 transcriptional activity (IC50: 1.9 ± 0.4 and 1.4 ± 0.2 μM, respectively). Both compounds suppressed HIF-1α accumulation in a concentration-dependent manner. The porcine heart malate dehydrogenase (MDH) refolding assay revealed that compound 1l inhibited human Hsp60 chaperone activity (IC50: 6.80 ± 0.25 μM) and this inhibition activity was higher than that of ETB (IC50: 10.9 ± 0.63 μM).