1114507-71-9Relevant academic research and scientific papers
Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (5-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants
Radi, Marco,Maga, Giovanni,Alongi, Maddalena,Angeli, Lucilla,Samuele, Alberta,Zanoli, Samantha,Bellucci, Luca,Tafi, Andrea,Casaluce, Gianni,Giorgi, Gianluca,Armand-Ugon, Mercedes,Gonzalez, Emmanuel,Este, José A.,Baltzinger, Mireille,Bec, Guillaume,Dumas, Philippe,Ennifar, Eric,Botta, Maurizio
supporting information; experimental part, p. 840 - 851 (2009/12/26)
The role played by stereochemistry in the C2-substituent (left part) on the S-DABO scaffold for anti-HIV-1 activity has been investigated for the first time. A series of S-DABO analogues, where the double bond in the C2-substituent is replaced by an enant
