1114523-56-6

Basic information

• Product Name: 1-(2-BroMo-5-fluoropyridin-4-yl)ethanone
• Synonyms: 1-(2-BroMo-5-fluoro-4-pyridinyl)-ethanone;Ethanone, 1-(2-bromo-5-fluoro-4-pyridinyl)-;1-(2-BroMo-5-fluoropyridin-4-yl)ethanone
• CAS NO: 1114523-56-6
• Molecular Formula: C7H5BrFNO
• Molecular Weight: 218.0231032
• Mol File: 1114523-56-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-BroMo-5-fluoropyridin-4-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BroMo-5-fluoropyridin-4-yl)ethanone(1114523-56-6)
• EPA Substance Registry System: 1-(2-BroMo-5-fluoropyridin-4-yl)ethanone(1114523-56-6)

Safety Data

• Hazardous Substances Data: 1114523-56-6(Hazardous Substances Data)

Usage

General Description

1-(2-Bromo-5-fluoropyridin-4-yl)ethanone is a chemical compound with the molecular formula C7H6BrFNO. It is a yellowish solid with a molecular weight of 206.03 g/mol. 1-(2-BroMo-5-fluoropyridin-4-yl)ethanone is used in organic synthesis and pharmaceutical research as a building block for the synthesis of diverse compounds and pharmaceuticals. It is also used as a reagent in chemical reactions for the modification and functionalization of organic molecules. Additionally, 1-(2-Bromo-5-fluoropyridin-4-yl)ethanone may have potential applications in the development of new drugs and materials due to its unique chemical structure and properties. Overall, this compound is important in the field of organic chemistry and has various applications in research and industry.

Upstream product

• 41404-58-4 2-bromo-5-fluoropyridine 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 1114523-54-4 1-(2-bromo-5-fluoropyridin-4-yl) ethanol 

Downstream Products

• 929617-30-1 5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine 

Relevant articles and documents

Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype

This Letter details our efforts to discover structurally unique M4 PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of the 2,3-dimethyl-2H-indazole-5-carboxamide and 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxamide cores, we investigated a plethora of core replacements. This exercise identified a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide core that provided improved M4 PAM activity and CNS penetration.

IMINOTHIADIAZINE DIOXIDES BEARING AN AMINE-LINKED SUBSTITUENT AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R2, ring A, RA, m, ringB, RB, and n are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

C2-CARBOCYCLIC IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R2, ring A, RA, m, ring B, RB, n, ring C, RC and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.