111453-25-9Relevant academic research and scientific papers
PROCESS FOR THE ATOMIZATION OF IOXILAN
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Page/Page column 7; Fig.1, (2008/06/13)
The invention relates to a process for the preparation of ioxilan of formula 5-[N- (2,3-dihydroxypropyl)acetamido]-2,4,6-triiodo-N-(2,3-dihydroxypropyl)-N'-(2- hydroxyethyl)isophthalamide by atomization and to the improved product thus obtained. This process makes it possible to avoid a process by crystallization and results in an active principle having an improved solubility.
Carboxamide non-ionic contrast media
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, (2008/06/13)
Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.
Non-ionic polyol contrast media from ionic contrast media
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, (2008/06/13)
Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
