1114543-47-3

Basic information

• Product Name: N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide
• Synonyms: N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide ;1-{[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}-2-({[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}sulfanyl)-1H-1,3-benzodiazole;1-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridinyl]Methyl]-2-[[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridinyl]Methyl]thio]-1H-benziMidazole;Rabeprazole N-Alkyl Sulfide;Rabeprazolesodium Impurity V
• CAS NO: 1114543-47-3
• Molecular Formula: C29H36N4O4S
• Molecular Weight: 536.68554
• Product Categories: Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1114543-47-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 707.2±70.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 6.15±0.30(Predicted)
• CAS DataBase Reference: N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide(1114543-47-3)
• EPA Substance Registry System: N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfide(1114543-47-3)

Safety Data

• Hazardous Substances Data: 1114543-47-3(Hazardous Substances Data)

Usage

Uses

Rabeprazole (R070500) N-aralkyl impurity.

Upstream product

• 134469-07-1 Benzimidazol-2-thiol 

Relevant articles and documents

Synthesis of metabolites and related substances of rabeprazole, an anti-ulcerative drug

Rabeprazole sodium (Aciphex) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds. Copyright Taylor & Francis Group, LLC.