111455-61-9

Upstream product

• 2531-11-5 4β-acetoxy-3α,15-dihydroxy-12,13-epoxytrichothec-9-ene 
• 111556-00-4 3α,4β-diacetoxy-10β-bromo-9α,15;12,13-diepoxytrichothecane 
• 107954-43-8 4β-acetoxy-10β-bromo-3α-hydroxy-9α,15;12,13-diepoxytrichothecane 
• 111455-60-8 3α,4β-diacetoxy-10β-bromo-9α,15-epoxytrichothec-12-ene 

Downstream Products

• 4297-61-4 3α,4β,15-triacetoxy-12,13-epi-epoxytrichothec-9-ene 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of a Trichothecene epi-Epoxide, 3α,4β,15-Triacetoxy-12,13-epi-epoxytrichothec-9-ene

In order to provide additional insight into the mode of action of the trichothecene mycotoxins, one of the first semi-synthetic trichothecene epi-epoxides (8) has been prepared; in dramatic contrast to its natural isomer (9), this compound proved tobe devoid of significant biological activity.

Trichothecene mycotoxin interconversions: Partial syntheses of calonectrin and deoxynivalenol, and of a trichothecene epi-epoxide, 3α,4β,15-triacetoxy-12,13-epi-epoxytrichothec-9-ene

The partial syntheses of two trichothecenes, calonectrin (4β,15-diacetoxy-12,13-epoxytrichothec-9-ene) and deoxynivalenol (3α,7α,15-trihydroxy-12,13-epoxytrichothec-9-ene), from a readily available trichothecene, anguidine (4β,15-diacetoxy-3α-hydroxy-12,13-epoxytrichothec-9-ene) are described. In addition, and in order to provide further insight into the mode of action of the trichothecene mycotoxins, 3α,4β,15-tricetoxy-12,13-epi-epoxytrichothec-9-ene, of the first semisynthetic trichothecene epi-epoxides, has been prepared and its X-ray crystal structure determined. In significant contrast to its natural isomer, epi-epoxide proved to be biologically inactive.