1114568-10-3Relevant academic research and scientific papers
Examination of the olefin-olefin ring closing metathesis to prepare Latrunculin B
She, Jin,Lampe, John W.,Polianski, Alexandra B.,Watson, Paul S.
supporting information; experimental part, p. 298 - 301 (2009/04/14)
Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin-olefin ring closing metathesis chemistry to close the 14-membered macrocycle. Metathesis reactions of substrates with various remote protecting group patterns were examined and gave 6,7-E-lactones as the preferred products.
