1114592-95-8Relevant academic research and scientific papers
N-Substituted-2-alkyl- and 2-arylnorapomorphines: Novel, highly active D2 agonists
Herm, Laura,Berenyi, Sandor,Vonk, Argo,Rinken, Ago,Sipos, Attila
experimental part, p. 4756 - 4762 (2009/12/01)
Two synthesis routes have been elaborated for the preparation of novel N-substituted-2-alkyl- and 2-arylnorapomorphines. The first one utilizes the traditional methodology of N-substitution of morphinans before acid-catalyzed rearrangements into aporphino
Synthesis of pharmacologically active apomorphines by direct N-substitution on the aporphine backbone
Sipos, Attila,Berényi, Sándor
body text, p. 1703 - 1705 (2009/05/11)
A method has been developed for the direct N-substitution of aporphines comprising the N-oxidation-N-deprotection-N-alkylation sequence. This methodology was found to be insensitive to the change in the substitution pattern of rings A or D, therefore it is presumed to be applicable also for aporphines derived from total synthesis and natural sources. Thieme Stuttgart.
