111463-18-4

Basic information

• Product Name: METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE
• Synonyms: METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE
• CAS NO: 111463-18-4
• Molecular Formula: C8H11ClO5
• Molecular Weight: 222.62
• Mol File: 111463-18-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE(111463-18-4)
• EPA Substance Registry System: METHYL 2-(2-((CHLOROCARBONYL)METHYL)-1,3-DIOXOLAN-2-YL)ACETATE(111463-18-4)

Safety Data

• Hazardous Substances Data: 111463-18-4(Hazardous Substances Data)

Relevant articles and documents

Process for intermediates to 1-carbapenems and 1-carbacephems

A stereoselective process for chiral intermediates to 1-carbapenum and 1-carbacephalosporins is provided comprising the use of an N-acyl-(4R)-substituted-1,3-thiazolidine-2-thione as a chiral auxiliary in boron enolate mediated aldol condensation with a protected-β-keto ester aldehyde. E.g., benzyl 3,3-(ethylenedioxy)-4-formylbutyrate is condensed with the boron enolate formed with n-butyryl (4R)-methoxycarbonyl-1,3-thiazolidine-2-thione to provide benzyl 3,3-ethylenedioxy-(5R)-hydroxy-6-[(4R)-methoxycarbonyl-1,3-thiazolidine-2-thione-3-ylcarbonyl]octanoate. Displacement of the thiazolidine-2-thione chiral auxiliary moiety with an O-alkyl, O-acyl or O-aralkyl hydroxyamine provides the corresponding chiral intermediate as the hydroxamate.