111468-94-1 Usage
Uses
Used in Pharmaceutical Industry:
4-PROPIONYL-1H-PYRROLE-2-CARBOXYLIC ACID is used as a precursor in the synthesis of potential drug candidates for various therapeutic applications. Its unique structure and functional groups make it a versatile building block in medicinal chemistry, contributing to the development of novel and effective pharmaceuticals.
Used in Organic Synthesis:
In the field of organic synthesis, 4-PROPIONYL-1H-PYRROLE-2-CARBOXYLIC ACID serves as an important intermediate. Its presence in the synthesis process allows for the creation of a diverse range of organic compounds, expanding the scope of chemical research and innovation.
Used in Medicinal Chemistry:
4-PROPIONYL-1H-PYRROLE-2-CARBOXYLIC ACID is utilized as a building block in medicinal chemistry, where it contributes to the design and synthesis of biologically active compounds. Its structural features and reactivity make it a key component in the development of new pharmaceutical agents with potential therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 111468-94-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,4,6 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 111468-94:
(8*1)+(7*1)+(6*1)+(5*4)+(4*6)+(3*8)+(2*9)+(1*4)=111
111 % 10 = 1
So 111468-94-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-2-7(10)5-3-6(8(11)12)9-4-5/h3-4,9H,2H2,1H3,(H,11,12)/p-1
111468-94-1Relevant academic research and scientific papers
Synthesis of 2-Alkylputrescines from 3-Alkylpyrroles
Garrido, Daniel O. A.,Buldain, Graciela,Ojea, Maria I.,Frydman, Benjamin
, p. 403 - 407 (2007/10/02)
Acylation of 2-(trichloroacetyl)pyrrole gave the 4-acyl derivatives (from 4-formyl to 4-hexanoyl) in good yields.Alkaline treatment gave corresponding 4-acyl-2-pyrrolecarboxylic acids, were decarboxylated to the 3-acylpyrroles by prior conversion to the 3-acyl-2,4,5-triiodopyrroles followed by hydrogenolysis.The 3-acylpyrroles were reduced by treatment with hydrazine in alkaline medium to the 3-alkylpyrroles.The latter were ring-opened by treatment with hydroxylamine in the presence of bicarbonate to give the dioximes of the corresponding 2-alkylsuccinaldehydes, which were then reduced to the 2-alkylpurescines (1,4-diaminobutanes).Ring-opening of 2,3-dimethylpyrrole followed by reduction of the dioxime gave 1,2-dimethylputrescine; the same sequence gave 1,3-dimethylputrescine from 2,4-dimethylpyrrole, while 3,4-dimethylpyrrole did not ring-open and gave the dioxime of 3,4-dimethylmaleimide.
