111479-04-0Relevant academic research and scientific papers
Preparation method of ilepcimide
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Paragraph 0050; 0052-0053; 0054; 0056-0057; 0058; 0060-0061, (2021/10/11)
The invention provides a preparation method of ilepcimide. The preparation method comprises the following step: in the presence of a catalyst, reacting raw materials containing 4-bromo-1, 2-methylenedioxybenzene, an acrylate compound and piperidine to obtain the ilepcimide. The preparation method disclosed by the invention is good in selectivity, reduces side reactions, increases the conversion rate and yield of the product, reduces the use of toxic and irritant raw materials, saves the treatment cost of three wastes, is a green and environment-friendly process, and is suitable for industrial production, and the molar yield is 76% or above, and the purity is 99% or above.
